Evidence map›Paper›PMID 42835070›Full record

ArticleKidney international reports2026

Systematic Review of Persistent Microscopic Hematuria and Kidney Outcomes in IgAN.

Gian Marco Berti, Daniele Vetrano, Edoardo Tringali, Francesco Tondolo, Chiara Cantarelli, Gisella Vischini, Elisa Gessaroli, Giorgia Comai, Gaetano La Manna, Federica Martitati

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Article in Kidney international reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

10 authors.

Gian Marco BertiDepartment of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Daniele VetranoDepartment of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Edoardo TringaliNephrology and Dialysis Unit, ASL TO4, Turin, Italy.
Francesco TondoloNephrology, Dialysis and Kidney Transplant Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Chiara CantarelliDepartment of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Gisella VischiniNephrology, Dialysis and Kidney Transplant Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Elisa GessaroliDepartment of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Giorgia ComaiDepartment of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Gaetano La MannaDepartment of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Federica MartitatiNephrology, Dialysis and Kidney Transplant Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: IgA nephropathy (IgAN) is a common glomerulonephritis, but the prognostic relevance of persistent microscopic hematuria remains uncertain. Persistent hematuria may reflect glomerular inflammation and complement proteinuria and estimated glomerular filtration rate (eGFR) in longitudinal assessment. We evaluated its association with kidney outcomes. Methods: MEDLINE, Embase, and Web of Science were searched through July 28, 2026, for studies evaluating longitudinal or persistent microscopic hematuria in IgAN. Categorical time-to-event estimates were pooled as hazard ratios (HRs) using random-effects models. Adjusted estimates were prioritized, and heterogeneity was assessed using the Results: A total of 9 reports representing 8 independent cohorts and 4776 participants were eligible. In the analysis including the Yu Conclusions: Persistent microscopic hematuria is associated with kidney disease progression in IgAN. Longitudinal assessment may provide additional prognostic information alongside conventional biomarkers. Prospective studies should define its role in risk stratification and treatment monitoring.

Indexed as

glomerular filtration ratehematuriaIgA nephropathykidney disease progressionmeta-analysisprognosis

Identifiers

PMID42835070
PMCPMC13634875

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