ReviewBritish journal of biomedical science2026
REV-ERBs as regulators of circadian rhythm, neuroinflammation, and glial lipid homeostasis in Alzheimer's disease. A narrative review.
Review in British journal of biomedical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Alzheimer's disease (AD) is characterized by progressive cognitive decline, amyloid-β and tau aggregation, and chronic neuroinflammation, processes that are tightly coupled to circadian and metabolic dysfunction. REV-ERBα (NR1D1) and REV-ERBβ (NR1D2) are ligand-dependent nuclear receptors that function as transcriptional repressors within the core clock and coordinate programs governing lipid metabolism, innate immunity, and redox homeostasis in the brain. In microglia, REV-ERBα restrains NF-κB signaling, complement and inflammasome activation, and lipid droplet accumulation, thereby limiting synaptic engulfment and tauopathy progression, whereas its loss drives a hyper-reactive, neurotoxic state. Astrocytic REV-ERBα exerts context-dependent effects, simultaneously constraining cytokine and nitric oxide production while tuning NAD
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