Evidence map›Paper›PMID 42834995›Full record

ArticleiScience2026

Immature olfactory sensory neurons provide complementary input in the intact olfactory system.

Jordan D Gregory, Ryan S Herzog, Kendall A Curtis, Michael I Marar, Claire E J Cheetham

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jordan D GregoryDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Ryan S HerzogDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Kendall A CurtisDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Michael I MararDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Claire E J CheethamDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

Funding

Functional Integration of Newborn Olfactory Sensory Neurons in the Healthy and Regenerating Olfactory SystemR01DC018516 · NIDCD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEETHAM, CLAIRE ELIZABETH JANE · 2021 to 2025
$1.8M
NIDCD NIH HHS R01 DC018516
6 · The paper itself

Abstract

Adult neurogenesis of olfactory sensory neurons (OSNs) provides the unique opportunity to understand how new neurons functionally integrate into existing circuitry and contribute to behaviors. Previous studies have shown that immature OSNs provide odor input to neurons in the mouse OB, and that, in mice lacking mature OSNs, sensory input from immature OSNs can mediate odor detection and discrimination. What remains unknown is how immature OSNs contribute to odor-guided behavior in the intact olfactory system. Here we show that acute chemogenetic silencing of immature OSNs impairs performance in a buried food assay, potentially by altering odor detection. Furthermore, acute immature OSN silencing reduces the amplitude of odor-evoked dendritic calcium responses in OB neurons

Indexed as

olfactory bulbolfactory sensory neuronpostnatal neurogenesis

Identifiers

PMID42834995
PMCPMC13635011

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.