ArticleFrontiers in oncology2026
Clinical outcomes of pembrolizumab plus gemcitabine and cisplatin in a Japanese institutional subgroup of KEYNOTE-966: a dexamethasone-minimizing supportive-care approach.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: KEYNOTE-966, a double-blinded randomized controlled phase III trial comparing pembrolizumab/placebo + gemcitabine + cisplatin (GC) for biliary tract cancer [BTC], demonstrated the efficacy and safety of addition of pembrolizumab to GC. The effect of steroid and antibiotics use on immune check-point inhibitors is still of interest. Methods: This was a Results: It was found that there were 22 and 16 patients in the Pembrolizumab+GC and Placebo+GC groups, respectively. The hazard ratios (HRs) of overall survival (OS) and progression-free survival (PFS) for the Pembrolizumab+GC group were 0.622 (95% confidence interval [CI], 0.318-1.217) and 0.360 (95% CI, 0.178-0.728), respectively; the objective response rates were 31.8% and 6.3%, respectively. The HR for OS and PFS in the multivariable and IPW analyses were numerically similar to those in the original analysis, which was better than that observed in the entire KEYNOTE-966 cohort. Discussion: Our experience of Pembrolizumab + GC over Placebo +GC generates a clinical question whether the efficacy of Pembrolizumab may be enhanced when antibiotics and antiemetic DEX are avoided.
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