ArticleFrontiers in neurology2026
Hypothalamic subregional volume in relation to VSS-C total symptom burden in women with migraine: an exploratory cross-sectional MRI study.
Article in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Dizziness, vertigo, and related autonomic symptoms are common in migraine, but whether their combined symptom-frequency burden is associated with hypothalamic subregional structure remains unclear. Methods: This exploratory cross-sectional secondary analysis included 39 women with ICHD-3-defined migraine. All source T1-weighted images were processed uniformly with FreeSurfer 7.4.1 and automated hypothalamic subunit segmentation. Blinded quality control was performed without clinical data and independently confirmed by a neuroradiologist. The exposure was VSS-C total score, a composite of vertigo-balance and autonomic-anxiety symptom frequency. Models for five bilateral subunits and whole-hypothalamus volume adjusted for age, estimated total intracranial volume, and baseline monthly migraine days; Benjamini-Hochberg false-discovery-rate correction was applied across the six outcomes. Outcome-specific quality-control denominators were 37 or 39. Results: Anterior-superior hypothalamic volume was associated with VSS-C total score (n = 39; β = 0.165 mm Conclusion: Higher VSS-C total symptom burden was associated with larger anterior-superior hypothalamic volume in women with migraine. This result identifies a subregional target for prospective replication with component-level symptom assessment and formal vestibular phenotyping.
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