ArticleLiver international : official journal of the International Association for the Study of the Liver2026
Intrahepatic Tissue-Resident CD8
Article in Liver international : official journal of the International Association for the Study of the Liver, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Intrahepatic Tissue-Resident CD8Liver international : official journal of the International Association for the Study of the Liver · 2026Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsAutoimmune hepatitis is an immune-mediated liver disease characterized by chronic inflammation and progressive fibrosis. Tissue-resident memory T cells mediate organ-specific immunity, but their role in autoimmune hepatitis remains poorly understood. We characterized tissue-residency-associated T-cell populations and their cytokine profiles, assessed associations with disease severity and determined whether these signatures were reflected in peripheral blood.
methodsPaired blood and liver samples were obtained from 19 patients with autoimmune hepatitis. Comparator cohorts included 20 patients with metabolic dysfunction-associated steatotic liver disease and 20 surgical patients providing non-inflamed adjacent non-tumorous liver tissue. Multiparameter flow cytometry assessed tissue-residency markers, T-cell differentiation and cytokine production after polyclonal stimulation. Immune phenotypes were correlated with histological and clinical parameters.
resultsAutoimmune hepatitis was associated with compartment-specific remodelling of T-cell differentiation states and intrahepatic enrichment of CD8
conclusionsAutoimmune hepatitis was characterized by intrahepatic accumulation of phenotypically distinct and functionally active CD8
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