ArticleActa obstetricia et gynecologica Scandinavica2026
Risk factors for infection after hysterectomy for benign disease.
Article in Acta obstetricia et gynecologica Scandinavica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionOur objective was to identify risk factors for infections following hysterectomy for benign disease. MATERIAL AND
methodsThis population-based cohort study included hysterectomies recorded in the Swedish National Quality Register for Gynecological Surgery (GynOP) between 2005 and 2022. Data were linked with the Swedish Prescribed Drug Register, the National Patient Register, and Statistics Sweden. Postoperative infection was defined as a dispensed systemic antibiotic prescription within 21 days postoperatively (i.e., not local antibiotics or injectables). Crude and adjusted risk ratios (aRRs) were estimated using modified Poisson regression, adjusting for preoperative medications, demographic and perioperative factors.
resultsAmong 50 601 hysterectomies, 7153 women (14.1%) had a dispensed prescription of antibiotics postoperatively. Younger age, antidepressant or psycholeptic use, and previous abdominal or cesarean surgery were associated with increased risk of dispensed antibiotics. Endometriosis (aRR 1.30, 95% CI 1.06-1.58), preoperative use of immunoregulatory drugs (aRR 1.48, 95% CI 1.09-2.00), and Body Mass Index (BMI) ≥40 kg/m
conclusionsPrescribed and dispensed antibiotics after benign hysterectomy are common and influenced by several patient- and surgical factors. Identification of high-risk patients such as women with high BMI or using immunomodulating drugs, patients with endometriosis or previous abdominal surgery may support individualized preventive strategies and improve postoperative outcomes.
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