Evidence map›Paper›PMID 42834410›Full record

ArticleRespiratory research2026

Multi-cell death gene signature predicts lung adenocarcinoma prognosis and reveals FURIN regulates ferroptosis via NRF2-xCT-GPX4 axis.

Jiaoyang Ning, Gang Xiao, Su Wen, Liu Chen, Ce Wang, Keqin Zhang, Hao Wen, Guilong Tanzhu, Jie Yang, Rongrong Zhou

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Article in Respiratory research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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10 authors.

Jiaoyang Ning *Department of Radiation Oncology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Gang Xiao *Department of Radiation Oncology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Su WenDepartment of Radiation Oncology, The Affiliated Hospital of Xiangya School of Medicine, Hunan Cancer Hospital, Central South University, Changsha, 410013, China.
Liu ChenDepartment of Radiation Oncology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Ce WangDepartment of Radiology, China-Japan Friendship Hospital, Beijing, 100029, China.
Keqin ZhangDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, 410078, China.
Hao WenDepartment of Radiation Oncology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Guilong TanzhuDepartment of Radiation Oncology, Xiangya Hospital, Central South University, Changsha, 410008, China. tzgl2716@126.com.
Jie YangDepartment of Radiation Oncology, Xiangya Hospital, Central South University, Changsha, 410008, China. yangjie@csu.edu.cn.
Rongrong ZhouDepartment of Radiation Oncology, Xiangya Hospital, Central South University, Changsha, 410008, China. zhourr@csu.edu.cn.

Funding

Natural Science Foundation of Hunan Province 2022JJ30992
6 · The paper itself

Abstract

backgroundFURIN, a proprotein convertase, has been implicated in tumor progression. Nevertheless, how it contributes to lung adenocarcinoma (LUAD) and ferroptosis is still not well understood.

methodsWe investigated FURIN expression and its prognostic value using the TCGA-LUAD cohort, CPTAC, and GEO datasets. In vitro functional assays, including CCK-8, colony formation, EdU, wound healing, invasion, and tube formation, were conducted in HCC827, PC9 and H460 cells following FURIN knockdown, with or without the ferroptosis inhibitor Ferrostatin-1 (Fer-1). RNA-seq, ferroptosis signature scoring, and GSEA were used to explore mechanisms. Ferroptosis was assessed by ROS and Fe accumulation, MDA and GSH/GSSG ratio, T-AOC, and ferroptosis-related protein expression. Preliminary exploration of the mechanism by which FURIN regulates NRF2 was performed using confocal microscopy. A multiple cell death-related gene signature was developed for prognostic prediction and immune/mutational landscape analysis.

resultsIn LUAD, FURIN was highly expressed and linked to poor prognosis. Knockdown of FURIN suppressed proliferation, migration, invasion, and angiogenesis, accompanied by increased ROS, Fe

conclusionsFURIN promotes LUAD progression by suppressing ferroptosis through the NRF2-xCT-GPX4 axis. Targeting the FURIN-ferroptosis axis and using ferroptosis-based risk stratification may offer novel strategies for prognosis and individualized therapy.

Indexed as

Adenocarcinoma of LungAmino Acid Transport System y+FerroptosisFurinLung NeoplasmsNF-E2-Related Factor 2Phospholipid Hydroperoxide Glutathione PeroxidaseCell Line, TumorGene Expression Regulation, NeoplasticHumansPrognosisAmino Acid Transport System y+FurinFURIN protein, humanNFE2L2 protein, humanNF-E2-Related Factor 2Phospholipid Hydroperoxide Glutathione PeroxidaseSLC7A11 protein, humanFerroptosisFURINImmune infiltrationLung adenocarcinomaMutationPrognosis

Identifiers

PMID42834410
PMCPMC13637139

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