ArticleBMC gastroenterology2026
Clinical and pathological characteristics of mucinous adenocarcinoma in colon cancer: comparison with classic adenocarcinoma.
Article in BMC gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundMucinous adenocarcinoma of the colon is defined by extracellular mucin occupying at least 50% of the tumour. Although it is often regarded as a distinct histological subtype, its clinicopathological profile remains variable across published series. We compared mucinous and classic adenocarcinoma in a colon-only surgical cohort.
methodsWe retrospectively reviewed patients who underwent oncological resection for colon adenocarcinoma between October 2021 and March 2026. Rectal tumours, neoadjuvant-treated cases and signet ring cell carcinoma were excluded. Clinicopathological variables were compared using Mann-Whitney U, Pearson chi-square or Fisher exact tests. Multivariable analyses were revised as parsimonious logistic regression models, with model size and event counts reported.
resultsThe final cohort included 155 colon cancers: 29 mucinous and 126 classic adenocarcinomas. Mucinous tumours were more often right-sided (75.9% vs. 44.4%; p = 0.002) and more frequently poorly differentiated (24.1% vs. 4.8%; p = 0.003). Advanced pT stage was common in both groups (86.2% vs. 82.5%; p = 0.786). Nodal metastasis was numerically less frequent in mucinous adenocarcinoma (31.0% vs. 50.8%; p = 0.055), while lymphovascular invasion was significantly less common (10.3% vs. 32.5%; p = 0.017). Deficient mismatch repair was recorded in 13.8% of mucinous tumours and 8.7% of classic adenocarcinomas (p = 0.484). In parsimonious adjusted models, mucinous histology was not independently associated with advanced pT stage (adjusted OR 1.51, 95% CI 0.46-4.92; p = 0.496) or nodal metastasis (adjusted OR 0.48, 95% CI 0.19-1.19; p = 0.113).
conclusionsIn this colon-only cohort, mucinous adenocarcinoma was associated with right-sided location and poor differentiation, but not with independently higher local invasion or nodal spread. These findings support a cautious, clinicopathology-based interpretation of mucinous histology and should not be extrapolated to prognosis without molecular and survival data.
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