ArticleEye (London, England)2026
Risk factors, microbiological profiles, and clinical outcomes of paediatric infectious keratitis: The Midlands Infectious Keratitis Study.
Article in Eye (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectivesTo characterise the clinical features, microbiological profiles, and outcomes of paediatric infectious keratitis (IK).
methodsThis retrospective multicentre study included paediatric patients (≤18 years old) who presented with presumed IK and underwent corneal sampling at two UK tertiary ophthalmic centres.
resultsWe included 42 cases in this study; median age was 13.3 years (IQR 10.1-16.1). Contact lens wear (15, 35.7%) and ocular surface disease (15, 35.7%) were the most common risk factors. Twenty-five (59.5%) cases were microbiologically positive (MP), with Pseudomonas aeruginosa (5, 16.1%), Staphylococcus aureus (5, 16.1%), and Serratia marcescens (5, 16.1%) being the most commonly isolated bacteria. Six (24.0%) cases were caused by polymicrobial infection (≥2 bacteria). Median presenting CDVA was 0.30 logMAR [0.20-1.30] and improved to 0.15 [0.00-0.75] at final follow-up (p < 0.001). Poor visual outcome (final CDVA > 0.6 logMAR) was observed in 11 (26.2%) cases and was associated with worse presenting CDVA (p = 0.010), prior corneal surgery (p = 0.003), and MP status (p = 0.016). Delayed corneal healing (>30 days) occurred in 17 (40.5%) cases. Complications were uncommon, including 3 (7.1%) recurrence, 2 (4.8%) corneal melt, and 1 (2.4%) perforation.
conclusionsPaediatric IK represents an important ocular morbidity in the UK. Contact lens wear was the most common risk factor and was strongly associated with P. aeruginosa infection, highlighting the need for improved awareness, education, and prevention. MP cases were associated with worse visual outcomes and features of greater disease severity. These findings support early recognition and appropriate management to optimise visual outcomes in this population.
Identifiers
42834129What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.