ReviewTrends in biotechnology2026
Translational benchmarking of 3D in vitro models of traumatic brain injury.
Review in Trends in biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
4 authors.
Funding
Abstract
Traumatic brain injury (TBI) remains a major cause of neurological disability, yet effective therapies are limited. Advances in 3D in vitro neural models, including organoids, scaffold-based constructs, and brain-on-a-chip systems, have provided new opportunities to study neurotrauma under controlled conditions. This review evaluates recent in vitro tissue platforms through a dual framework of mechanical fidelity and biological response, benchmarking applied injury conditions against human biomechanical reconstructions and assessing the coverage of downstream responses relative to TBI pathology. Many 3D models apply clinically relevant mechanical loading regimes and reproduce select phenotypes, but remain limited by inconsistent mechanical reporting, incomplete cellular complexity, and sparse modeling of chronic and repetitive injury. Addressing these challenges will improve the translational utility of next-generation platforms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.