Evidence map›Paper›PMID 42833707›Full record

ArticleBMJ open2026

Cost-effectiveness of differentiated HIV service delivery in North Wollo, Ethiopia: a retrospective study.

Tenaw Baye Tarekegn, Teshome Bitew Demelash

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Article in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

2 authors.

Tenaw Baye TarekegnDepartment of Pharmacy, Woldia University, Woldia, Ethiopia tenegnaw27@gmail.com.ORCID http://orcid.org/0000-0001-9348-1488
Teshome Bitew DemelashDepartment of Pharmacy, Debre Berhan University, Debre Birhan, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDifferentiated service delivery (DSD) models have been introduced to optimise HIV care by tailoring services to patient needs, but evidence on their cost-effectiveness in Ethiopia is limited.

objectiveTo evaluate the cost-effectiveness of DSD models for HIV care compared with standard of care (SOC) in North Wollo, Ethiopia. STUDY

designRetrospective economic evaluation using bottom-up microcosting from a healthcare provider perspective.

settingOne hospital and three health centres in North Wollo Zone, Ethiopia, from January 2024 to December 2024.

participants786 adults (≥18 years) on antiretroviral therapy, including 393 receiving DSD (across nine models: 6-month multimonth dispensing, 3-month multimonth dispensing, appointment spacing, community antiretroviral therapy (ART) groups (CAG), FastTrack, maternal and child health, peer-led, adolescent groups and key population models) and 393 receiving SOC.

main outcome measuresTotal annual cost per patient (USD), retention in care at 12 months (%) and incremental cost-effectiveness ratios (ICERs) expressed as cost per additional patient retained. STATISTICAL ANALYSIS: Costs were annualised at a 3% discount rate. ICERs were calculated comparing each DSD model to SOC. Deterministic one-way sensitivity analysis (±20% for medication cost and retention rate) assessed robustness.

resultsSOC had the highest annual cost per patient (US$295) and lowest retention (76.6%). All DSD models were dominant (lower cost, higher retention) with negative ICERs. CAG was the most cost-effective (US$199 per patient; 93.0% retention; ICER -5.85), followed by FastTrack (US$212; 92.9%; -5.09) and adolescent groups (US$238; 90.5%; -4.10). Sensitivity analyses confirmed robustness; no scenario reversed dominance.

conclusionDSD models, particularly CAG, FastTrack and adolescent groups, provide more cost-effective HIV care than SOC in Ethiopia by achieving higher retention at lower costs. Scaling up these models could optimise resource allocation and reduce health system burden.

Indexed as

Cost-Benefit AnalysisDelivery of Health CareHIV InfectionsAdolescentAdultAnti-HIV AgentsCost-Effectiveness AnalysisEthiopiaFemaleHealth Care CostsHumansMaleRetrospective StudiesYoung AdultAnti-HIV AgentsEthiopiaHealth economicsHIV & AIDS

Identifiers

PMID42833707
PMCPMC13646966

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.