Evidence map›Paper›PMID 42833284›Full record

ArticleCell proliferation2026

Targeting a Novel AREG

Xin Luo, Longbin Xiong, Zhaohui Zhou, Lihao Zhang, Yulu Peng, Xiangpeng Zou, Yixin Huang, Yisong Lin, Xiaofeng Yang, Zhanji Zhan and 5 more

Abstract read
In one paragraph

Article in Cell proliferation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xin LuoDepartments of Urology, Sun Yat-sen University Cancer Center, Guangzhou, China.ORCID https://orcid.org/0009-0004-1924-6489
Longbin XiongDepartments of Urology, Sun Yat-sen University Cancer Center, Guangzhou, China.
Zhaohui ZhouDepartments of Urology, Sun Yat-sen University Cancer Center, Guangzhou, China.
Lihao ZhangDepartments of Urology, Sun Yat-sen University Cancer Center, Guangzhou, China.ORCID https://orcid.org/0009-0002-3902-8089
Yulu PengDepartments of Urology, Sun Yat-sen University Cancer Center, Guangzhou, China.ORCID https://orcid.org/0000-0002-5213-4655
Xiangpeng ZouDepartments of Urology, Sun Yat-sen University Cancer Center, Guangzhou, China.
Yixin HuangDepartments of Urology, Sun Yat-sen University Cancer Center, Guangzhou, China.
Yisong LinDepartments of Urology, Sun Yat-sen University Cancer Center, Guangzhou, China.
Xiaofeng YangDepartments of Urology, Sun Yat-sen University Cancer Center, Guangzhou, China.
Zhanji ZhanState Key Laboratory of Organ Failure Research, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Fangjian ZhouDepartments of Urology, Sun Yat-sen University Cancer Center, Guangzhou, China.
Youhua LiuState Key Laboratory of Organ Failure Research, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0002-4740-805X
Chunping YuDepartment of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0003-2310-3777
Baokui YeState Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.ORCID https://orcid.org/0000-0002-9357-9810
Zhiling ZhangDepartments of Urology, Sun Yat-sen University Cancer Center, Guangzhou, China.ORCID https://orcid.org/0000-0003-1821-4587

Funding

China Postdoctoral Science Foundation 2023M734038China Postdoctoral Science Foundation 2024M763768Guangdong Natural Science Foundation 2024A1515010303Guangzhou Basic Research Program-City-University(Hospital)-Enterprise Joint Funding Project 2025A03J3620Guangzhou Medical Key Subject Construction Project 2025-2027National Natural Science Foundation of China 82273031National Natural Science Foundation of China 82273311National Natural Science Foundation of China 82303922National Natural Science Foundation of China 82373225National Natural Science Foundation of China 82472655National Natural Science Foundation of China 82503476National Natural Science Foundation of China 82503619National Natural Science Foundation of China 82573767the Chih Kuang Scholarship for Outstanding Young Physician-Scientists of Sun Yat-sen University Cancer Center CKS-SYSUCC-2024006the Chih Kuang Scholarship for Outstanding Young Physician-Scientists of Sun Yat-sen University Cancer Center CKS-SYSUCC-2025008the Guangzhou Science and Technology Project 2024A04J4319
6 · The paper itself

Abstract

Renal ischemia-reperfusion injury (RIRI) is a major cause of acute tubular damage and a key driver of maladaptive repair and fibrosis. However, the cellular initiators that connect early immune activation to tubular epithelial-mesenchymal transition (EMT) during RIRI remain poorly defined. Here, we established a human RIRI model by modifying the surgical procedures in patients undergoing radical nephrectomy and confirmed successful injury induction by tubular dilation, severe mitochondrial swelling and increased apoptosis in renal tissues. Using single-cell RNA sequencing, we uncovered an underappreciated dendritic cell (DC) subset, CD11c

Indexed as

epithelial mesenchymal transitionhuman ischemia–reperfusion injurykidney fibrosisradical nephrectomysingle cell sequencing

Identifiers

PMID42833284
PMCPMC13638235

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.