ArticleNeuroImage. Clinical2026
Increases in striatal response to reward anticipation relate to reductions in impulsivity in women with substance use disorders.
Article in NeuroImage. Clinical, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Impulsivity and neural reward reactivity are considered important factors in the development and maintenance of substance use disorders (SUDs) and may be predictive of treatment response. However, relationships between treatment response, impulsivity, and reward reactivity are understudied in women with SUDs. Our study aimed to characterize relationships between neural responses to reward anticipation and changes in behavioral and clinical outcomes following treatment. In a sample of adult women (N = 83) who completed a criminal diversion program that included comprehensive treatment for SUDs, nucleus accumbens (NAc) reactivity to reward and loss anticipation during a monetary incentive delay (MID) task was examined early in treatment (baseline) and one year later (follow-up). At baseline, more severe substance use symptoms were associated with elevated NAc reward anticipation while greater PTSD symptoms were associated with lower NAc loss anticipation. Symptoms of PTSD, substance use, and urgency significantly decreased by one-year follow-up (η
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