Evidence map›Paper›PMID 42832268›Full record

ArticleMicrobiology (Reading, England)2026

An extragenic fix for a broken enzyme.

Veena Mohan, Edoardo Labrini, Cemile Selin Aksoy, Volker Behrends, Laila C Evangelista, David R Spring, Martin Welch

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology (Reading, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Veena MohanDepartment of Biochemistry (Hopkins Building), University of Cambridge, Tennis Court Road, Cambridge, CB2 1QW, UK.
Edoardo LabriniDepartment of Biochemistry (Hopkins Building), University of Cambridge, Tennis Court Road, Cambridge, CB2 1QW, UK.
Cemile Selin AksoyDepartment of Biochemistry (Hopkins Building), University of Cambridge, Tennis Court Road, Cambridge, CB2 1QW, UK.
Volker BehrendsSchool of Medicine and Biosciences, University of West London, St. Marys Road, London, W5 5RF, UK.
Laila C EvangelistaDepartment of Surgery & Cancer, Institute of Reproductive Development Building, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.
David R SpringYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Martin WelchDepartment of Biochemistry (Hopkins Building), University of Cambridge, Tennis Court Road, Cambridge, CB2 1QW, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this work, we show how exploration of genomic sequence space yields an unexpected evolutionary 'fix' that allows the cell to bypass the phenotypic defects associated with a dysfunctional enzyme. We identified a transposon (Tn) insertion in the gene (

Indexed as

Bacterial ProteinsCarbon-Nitrogen LyasesPseudomonas aeruginosaArginineDNA Transposable ElementsMutagenesis, InsertionalMutationArginineBacterial ProteinsCarbon-Nitrogen LyasesDNA Transposable Elementsarginine metabolismauxotrophyenzyme regulationevolutionproteomicsPseudomonas aeruginosa

Identifiers

PMID42832268
PMCPMC13637947

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.