Evidence map›Paper›PMID 42832154›Full record

ArticleMolecular and cellular biochemistry2026

Sphingomyelin synthase 2 deficiency suppresses airway mucus accumulation by altering sphingolipid flux and mucin glycosylation.

Harumi Sakae, Kento Sonoda, Hikari Nishisaka, Yuri Ogiso, Ryoma Miyazaki, Masaya Matsuda, Takeshi Nabe, Ken Watanabe, Toshiro Okazaki, Tomoyuki Furubayashi and 2 more

Abstract read
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In one paragraph

Article in Molecular and cellular biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Harumi Sakae *Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotouge-Cho, Hirakata, Osaka, 573-0101, Japan.
Kento Sonoda *Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotouge-Cho, Hirakata, Osaka, 573-0101, Japan.ORCID http://orcid.org/0009-0003-0530-5858
Hikari NishisakaFaculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotouge-Cho, Hirakata, Osaka, 573-0101, Japan.
Yuri OgisoFaculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotouge-Cho, Hirakata, Osaka, 573-0101, Japan.
Ryoma MiyazakiFaculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotouge-Cho, Hirakata, Osaka, 573-0101, Japan.
Masaya MatsudaFaculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotouge-Cho, Hirakata, Osaka, 573-0101, Japan.ORCID http://orcid.org/0000-0001-6498-8335
Takeshi NabeFaculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotouge-Cho, Hirakata, Osaka, 573-0101, Japan.ORCID http://orcid.org/0000-0002-5225-8375
Ken WatanabeDepartment of Bone and Joint Disease, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
Toshiro OkazakiFaculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotouge-Cho, Hirakata, Osaka, 573-0101, Japan.
Tomoyuki FurubayashiLaboratory of Pharmaceutical Technology, Kobe Pharmaceutical University, Kobe, Hyogo, Japan.ORCID http://orcid.org/0000-0002-4397-4353
Makoto TaniguchiFaculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotouge-Cho, Hirakata, Osaka, 573-0101, Japan.
Kazuyuki KitataniFaculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotouge-Cho, Hirakata, Osaka, 573-0101, Japan. kazuyuki.kitatani@pharm.setsunan.ac.jp.ORCID https://orcid.org/0000-0002-8516-6135

Funding

Japan Society for the Promotion of Science 23K24187Japan Society for the Promotion of Science 24K08705
6 · The paper itself

Abstract

Sphingomyelin synthase 2 (SMS2) produces sphingomyelin from ceramide. In this study, SMS2 deficiency reduced airway accumulation of glycosylated mucins, such as MUC5AC, in a murine model of asthma, prompting investigation of the molecular mechanisms in mucin-forming epithelial cells. In the cell model, SMS2 silencing promoted the conversion of ceramide to glucosylceramide, a precursor of complex glycosphingolipids. This alteration reduced MUC5AC glycosylation, suggesting the potential for biochemical competition between sphingolipids and MUC5AC for glycosylation. Supplying C

Indexed as

CeramideGlycosylationMucusSphingolipidsSphingomyelinSphingomyelin synthase

Identifiers

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.