Evidence map›Paper›PMID 42832067›Full record

ArticleJournal of molecular medicine (Berlin, Germany)2026

Vascular smooth muscle-specific NLRP3 hyperactivation exacerbates arterial intimal hyperplasia in mice.

Yun-Ting Wang, Alexandra K Moura, Rui Zuo, Wei Gao, Bradley K McConnell, Guangbi Li, Pin-Lan Li, Xiang Li, Yang Zhang

Abstract read
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In one paragraph

Article in Journal of molecular medicine (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yun-Ting WangDepartment of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, 77001, USA.
Alexandra K MouraDepartment of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, 77001, USA.
Rui ZuoDepartment of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, 77001, USA.
Wei GaoDepartment of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, 77001, USA.
Bradley K McConnellDepartment of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, 77001, USA.
Guangbi LiDepartment of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, VA, 3305, USA.
Pin-Lan LiDepartment of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, VA, 3305, USA.
Xiang LiDepartment of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, 77001, USA. xli61@central.uh.edu.
Yang ZhangDepartment of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, 77001, USA. yzhan219@central.uh.edu.ORCID http://orcid.org/0000-0002-8338-3013

Funding

Lysosome Trafficking Dysregulation of Arterial Myocytes in AtherogenesisR01HL122937 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI LI, PINLAN, ZHANG, YANG · 2014 to 2024
$4.0M
National Heart, Lung, and Blood Institute (US) R01HL150007NHLBI NIH HHS R01HL122937
6 · The paper itself

Abstract

Intimal hyperplasia is a major contributor to restenosis after vascular interventions and to atherosclerotic lesion progression, involving vascular smooth muscle cell (VSMC) inflammatory activation, phenotypic switching, and maladaptive remodeling. Although NOD-like receptor pyrin domain 3 (NLRP3)-associated inflammatory signaling has been linked to vascular diseases, in vivo evidence defining how VSMC-intrinsic NLRP3 hyperactivation contributes to VSMC dysfunction and intimal hyperplasia remains limited. Here, we generated a VSMC-specific Nlrp3 gain-of-function (GOF) knock-in (KI) mouse model (Nlrp3

Indexed as

Muscle, Smooth, VascularNLR Family, Pyrin Domain-Containing 3 ProteinTunica IntimaAnimalsDisease Models, AnimalHyperplasiaMaleMiceMice, Inbred C57BLMyocytes, Smooth MuscleNeointimaSignal TransductionNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseGSDMDIntimal hyperplasiaLysosome-autophagyNLRP3-associated signalingTFEBVSMC

Identifiers

PMID42832067

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.