Cardiovascular Morbidity and Mortality in Chronic Hypoparathyroidism: A Systematic Review and Meta-Analysis.

Deep Dutta, Kunal Mahajan, Ashima Mittal, Oscar R Rivera, Bhavya Raja Gopal Yarlagadda, A B M Kamrul-Hasan

Abstract readSystematic ReviewMeta-Analysis

In one paragraph

Synthesis in Calcified tissue international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Deep DuttaDepartment of Endocrinology, Center for Endocrinology Diabetes Arthritis & Rheumatism (CEDAR) Superspeciality Healthcare, Dwarka, New Delhi, 110075, India. deepdutta2000@yahoo.com.ORCID http://orcid.org/0000-0003-4915-8805

Kunal MahajanDepartment of Cardiology, Himachal Heart Institute, Mandi, Himachal Pradesh, India.ORCID http://orcid.org/0000-0001-9378-6505

Ashima MittalDepartment of Endocrinology, UPMC Cole, Coudersport, PA, USA.ORCID http://orcid.org/0000-0001-9654-4966

Oscar R RiveraUniversidad Peruana de Ciencias Aplicada, Lima, Peru.ORCID http://orcid.org/0000-0001-9751-8401

Bhavya Raja Gopal YarlagaddaDepartment of Internal Medicine, Musc Health Lancaster Medical Center, Lancaster, USA.ORCID http://orcid.org/0000-0003-1860-7882

A B M Kamrul-HasanDepartment of Endocrinology, Mymensingh Medical College, Mymensingh, Bangladesh.ORCID http://orcid.org/0000-0002-5681-6522

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic hypoparathyroidism (HypoPT) may increase cardiovascular risk, yet current care rarely includes structured cardiovascular assessment. This systematic review and meta‑analysis aimed to quantify the association of chronic HypoPT with major cardiovascular events. Electronic databases and registries were searched from their inception through 10 June 2026 to identify controlled cohort studies of adults with chronic HypoPT and non-HypoPT comparators that reported cardiovascular outcomes. Random‑effects meta‑analyses (for hazard ratios [HRs]) were conducted for the primary and secondary outcomes using R. Data from nine cohort studies (N=134, 598; HypoPT: 28, 625; controls: 105, 973) were analyzed. HypoPT was associated with higher risk of myocardial infarction (MI) (HR1.19, 95%CI1.06, 1.35; I

Indexed as

Cardiovascular DiseasesHypoparathyroidismChronic DiseaseHumansArrhythmiasCardiovascular riskChronic kidney diseaseHeart failureHypoparathyroidismMI

Identifiers

PMID42832041

DOI10.3390/ijms222413536

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.