Evidence map›Paper›PMID 42831969›Full record

ArticleClinical drug investigation2026

Cognitive Outcomes After Reperfusion Therapy for Acute Ischaemic Stroke: A Systematic Review and Meta-analysis and the PRECISE-ACTION Framework for Transdisciplinary Cognitive Management.

Samprithi Raja, Robert Weissert, Zeljka Calic, Pravin Thomas, Jasvinder Chawla, Susana Mederer Hengstl, Ivica Smokovski, Olga Golubnitschaja, Tomotaka Tanaka, Kevin J Spring and 5 more

Abstract read
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In one paragraph

Article in Clinical drug investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Samprithi RajaGlobal Health Neurology Lab, Sydney, NSW, Australia.
Robert WeissertDepartment of Neurology, University Hospital Regensburg and University of Regensburg, Regensburg, Germany.ORCID http://orcid.org/0000-0002-1295-1271
Zeljka CalicGlobal Health Neurology Lab, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0003-0635-016X
Pravin ThomasDepartment of Neurology, Narayana Hospitals, Bengaluru, Karnataka, India.
Jasvinder ChawlaDepartment of Neurology, Loyola University Medical Center and Hines Veteran Affairs Hospital, Chicago, Illinois, USA.
Susana Mederer HengstlDepartment of Neurology, University Hospital Complex of Pontevedra, University of Santiago de Compostela, Pontevedra, Spain.
Ivica SmokovskiUniversity Clinic of Endocrinology, Diabetes and Metabolic Disorders, Skopje, North Macedonia.ORCID http://orcid.org/0000-0001-9567-8276
Olga GolubnitschajaPredictive, Preventive and Personalized (3P) Medicine, University Hospital Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0001-5427-2018
Tomotaka TanakaNational Cerebral and Cardiovascular Center (NCVC), Department of Neurology, Division of Cerebrovascular Medicine and Neurology, 6-1 Kishibeshinmachi, Suita, Osaka, 564-8565, Japan.ORCID http://orcid.org/0000-0002-6023-236X
Kevin J SpringUNSW Medicine and Health, University of New South Wales (UNSW), South West Sydney Clinical Campuses, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0003-0601-924X
Murray C KillingsworthUNSW Medicine and Health, University of New South Wales (UNSW), South West Sydney Clinical Campuses, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-6125-1183
Man Mohan MehndirattaDepartment of Neurology, B. L. Kapur Centre for Neurosciences, BLK-Max Super Specialty Hospital, Delhi, India.ORCID http://orcid.org/0000-0002-4428-9980
Rajesh N KalariaTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK.ORCID http://orcid.org/0000-0001-7907-4923
Masafumi IharaNational Cerebral and Cardiovascular Center (NCVC), Department of Neurology, Division of Cerebrovascular Medicine and Neurology, 6-1 Kishibeshinmachi, Suita, Osaka, 564-8565, Japan.ORCID http://orcid.org/0000-0002-7102-4048
Sonu M M BhaskarGlobal Health Neurology Lab, Sydney, NSW, Australia. Sonu.Bhaskar@globalhealthneurolab.org.ORCID http://orcid.org/0000-0002-9783-3628

Funding

Japan Society for the Promotion of Science 23KF0126Japan Society for the Promotion of Science P23712
6 · The paper itself

Abstract

backgroundPost-stroke cognitive impairment (PSCI) is disabling after acute ischaemic stroke (AIS), but cognitive outcomes after reperfusion therapy remain uncertain because studies differ in treatment pathways, cognitive tools, follow-up timing, and ascertainment.

objectivesTo estimate PSCI prevalence after AIS reperfusion therapy and evaluate comparative cognitive, safety, and functional outcomes.

methodsThis systematic review and meta-analysis searched PubMed/MEDLINE, Embase, and CENTRAL from 1 January 2000 to 31 May 2024, with an updated search on 16 June 2026. Random-effects models were used. Risk ratios (RRs) were the primary comparative binary measure; odds ratios (ORs) were sensitivity analyses.

resultsTwenty-eight distinct study records comprising 18,322 participants were included in this meta-analysis. Pooled PSCI prevalence was 33% in treatment-arm analyses (95% CI 14-54%; I

conclusionsPost-stroke cognitive impairment remains frequent after AIS reperfusion therapy, affecting approximately one-third of reperfusion-treated patients and two-fifths of overall or single-arm cohorts. Comparative RR and OR analyses did not show a robust overall association between reperfusion exposure and PSCI risk, while cognitive score differences were significant but heterogeneous. These findings support routine cognitive assessment, harmonised endpoints, and prospective therapy-specific follow-up. PRECISE-ACTION is proposed as a preliminary, hypothesis-generating transdisciplinary framework for structured cognitive assessment, longitudinal tracking, integrated care, and future research. REGISTRATION: Open Science Framework (OSF), 2nbeh.

Identifiers

PMID42831969

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.