Evidence map›Paper›PMID 42831945›Full record

ArticleJournal of neuro-oncology2026

Surgical characteristics and postoperative outcomes in a retrospective cohort study of patients with molecularly defined oligodendroglioma.

Anita L Kalluri, Austin Carmichael, Maureen Rakovec, Kelly Jiang, Megan Parker, Carly Weber-Levine, Divyaansh Raj, Josh Materi, Karisa C Schreck, Iban Aldecoa and 8 more

Abstract read
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Article in Journal of neuro-oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Anita L Kalluri *Department of Neurosurgery, Johns Hopkins University School of Medicine, Phipps Building, Room 100, 600 N. Wolfe Street, Baltimore, MD, 21287, USA.
Austin Carmichael *Department of Neurosurgery, Johns Hopkins University School of Medicine, Phipps Building, Room 100, 600 N. Wolfe Street, Baltimore, MD, 21287, USA.
Maureen RakovecDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Phipps Building, Room 100, 600 N. Wolfe Street, Baltimore, MD, 21287, USA.
Kelly JiangDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Phipps Building, Room 100, 600 N. Wolfe Street, Baltimore, MD, 21287, USA.
Megan ParkerDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Phipps Building, Room 100, 600 N. Wolfe Street, Baltimore, MD, 21287, USA.
Carly Weber-LevineDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Phipps Building, Room 100, 600 N. Wolfe Street, Baltimore, MD, 21287, USA.
Divyaansh RajDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Phipps Building, Room 100, 600 N. Wolfe Street, Baltimore, MD, 21287, USA.
Josh MateriDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Phipps Building, Room 100, 600 N. Wolfe Street, Baltimore, MD, 21287, USA.
Karisa C SchreckDepartments of Neurology and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Iban AldecoaDepartment of Pathology-CDB and Neurological Tissue Bank of the Biobank, Hospital Clínic-IDIBAPS-FCRB, Barcelona, Spain.
Kristin J RedmondDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Matthias HoldhoffDepartments of Neurology and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jon WeingartDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Phipps Building, Room 100, 600 N. Wolfe Street, Baltimore, MD, 21287, USA.
Henry BremDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Phipps Building, Room 100, 600 N. Wolfe Street, Baltimore, MD, 21287, USA.
Xiaobu YeDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Phipps Building, Room 100, 600 N. Wolfe Street, Baltimore, MD, 21287, USA.
Chetan BettegowdaDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Phipps Building, Room 100, 600 N. Wolfe Street, Baltimore, MD, 21287, USA.
Josep J González SánchezDepartment of Neurosurgery, Hospital Clínic i Provincial, Barcelona, Spain.
Jordina Rincon-TorroellaDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Phipps Building, Room 100, 600 N. Wolfe Street, Baltimore, MD, 21287, USA. jrincon2@jhmi.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOligodendroglioma, an adult diffuse glioma now defined by molecular criteria, is typically managed first surgically. This retrospective cohort study correlates surgical characteristics with postoperative outcomes in purely molecularly defined oligodendroglioma.

methodsAdults with surgically managed 1p/19q co-deleted, IDH-mutated oligodendroglioma were identified. Medical records were reviewed for demographics, radiologic features, treatments, and postoperative outcomes.

resultsTwo hundred seventy-seven patients (207 grade 2, 70 grade 3) were included; most presented with seizures (173/267, 64.8%), non-contrast enhancing lesions (128/213, 60.1%), and frontal lobe tumors (170/267, 63.7%). Subtotal resection (STR, 115/249, 46.2%) and gross total resection (GTR, 97/249, 39.0%) were more common than biopsy (37/249, 14.9%). Awake procedures were performed in 25/173 (14.5%) cases. New permanent neurological deficits occurred in 24/254 (9.4%) patients. Median (IQR) follow-up was 57 (20-107) months. Individuals undergoing GTR or STR had longer median progression-free survival (PFS) than patients who underwent biopsy (76 versus 44 months, p = 0.007). In multivariable analysis, GTR, but not STR, was an independent predictor of improved PFS compared to biopsy after adjusting for demographics, grade, and adjuvant treatment (p = 0.026). The PFS benefit of GTR over biopsy was maintained in subgroup analyses of grade 2 tumors (p = 0.032) but not grade 3 tumors (p = 0.549).

conclusionsIn this retrospective cohort of individuals with molecularly defined oligodendrogliomas, GTR was associated with prolonged PFS compared to biopsy without an observed increase in postoperative neurological deficits.

Indexed as

Brain NeoplasmsNeurosurgical ProceduresOligodendrogliomaAdultChromosomes, Human, Pair 1Chromosomes, Human, Pair 19FemaleFollow-Up StudiesHumansIsocitrate DehydrogenaseMaleMiddle AgedMutationPrognosisRetrospective StudiesTreatment OutcomeIsocitrate Dehydrogenase1p/19q co-deletionExtent of resectionIDH MutantMolecular oligodendrogliomaProgression free survival

Identifiers

PMID42831945

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.