ArticleInvestigative ophthalmology & visual science2026
Intraretinal Hyperreflective Foci as an OCT Feature Associated With Retinal Remodeling After Macular Hole Closure.
Article in Investigative ophthalmology & visual science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To investigate intraretinal hyperreflective foci (HF) within the foveola in the healing process following surgical closure of full-thickness macular holes (FTMHs), using lamellar macular holes (LMHs) and vitreomacular traction (VMT) as comparisons. Methods: Analysis of spectral-domain optical coherence tomography (OCT) scans from 48 FTMH eyes undergoing surgery was conducted, with 14 LMH and 10 VMT eyes serving as controls. HF were defined as dot-like intraretinal lesions with reflectivity similar to the retinal nerve fiber layer and without back-shadowing, showing a vertical distribution pattern within the foveola. Baseline OCT parameters, including minimal linear diameter, basal diameter, hole height, and macular hole index (MHI), defined as the ratio between hole height and basal diameter, were assessed. HF patterns were evaluated in relation to external limiting membrane (ELM) restoration and ellipsoid zone (EZ) integrity after surgery. Results: Among the 48 FTMH eyes, 43 achieved successful closure (89.6%). HF were identified in all 43 eyes achieving anatomical closure at the first postoperative assessment, compared with 50% in LMH and 50% in VMT controls (P < 0.001). HF preceded complete ELM restoration in nine of 43 eyes (20.9%), whereas in the remaining cases both events were detected simultaneously at the same postoperative visit. At final follow-up, HF persisted in 86.0% of eyes and were associated with baseline larger base diameter (P = 0.044) and baseline lower macular hole index (MHI; P = 0.007). Complete EZ integrity was achieved in 65.1% of eyes and was significantly associated with HF resolution (P = 0.047) and better final visual acuity (P = 0.038). Conclusions: HF displaying a vertical pattern within the foveola may represent an early structural OCT feature associated with retinal remodeling after macular hole surgery. Further studies are needed to determine their biological significance and potential role as an imaging marker of macular hole healing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.