Trial reportBJA open2026
Fasting-induced hypoglycaemia in anaesthetised paediatric patients (FIGS): protocol of an opt-out approach to consent for a multicentre cohort study measuring glycaemia and ketonaemia.
Trial report in BJA open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07259629 (Fasting Induced Hypoglycaemia in Anaesthetised Paediatric Patients), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Fasting Induced Hypoglycaemia in Anaesthetised Paediatric Patients
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0 citing papers in PubMed.
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Hypoglycaemia is a potentially a serious complication of the iatrogenic fasting required to deliver safe anaesthesia. Children may be at a higher risk because of their metabolic immaturity. Methods: This is a prospective multi-centre cohort study recruiting children fasting before a procedure under general anaesthesia. Children will have their blood glucose and ketones measured using point-of-care testing on venous blood drawn from a cannula inserted during i.v. or inhalation induction of general anaesthesia. The primary aim is to recruit as many children as possible across the four nations of the United Kingdom, using an opt-out approach to consent, to assess different thresholds used by anaesthetists to define hypoglycaemia and identify risk factors of this metabolic complication. The primary endpoint is the decision by anaesthetists to manage a hypoglycaemia at induction in a large paediatric population. Secondary endpoints are the actual values of glycaemia and ketonaemia and to evaluate the distributions of these parameters in a large paediatric population together with assessing potential risk factors of adverse metabolic responses to fasting (mainly hypoglycaemia, hypoketosis, and hyperketosis). The fasting-induced hypoglycaemia in anaesthetised paediatric patients (FIGS) study aims to recruit over 2000 children across the 4 nations of the United Kingdom. Trial recruitment is in progress starting May 2025 and expected to end May 2026, with analysis and results shared in 2027. Dissemintation Plans: This study, using an opt-out approach to consent, will provide a large data set of glycaemia and ketonaemia values in a paediatric population, assessing current practice, identifying risk factors, and building new recommendations for the management of the metabolic risk in fasting children. Clinical trial registrations: IRAS 329701 and NCT07259629. Protocol version number and date: 1.8, 14 April 2026.
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