Evidence map›Paper›PMID 42831220›Full record

ReviewFrontiers in cell and developmental biology2026

The silent dialogue between cells: regulatory roles of non-coding RNAs in cardiovascular disease.

Zhongwen Zhang, Yufei Yang, Mengzhen Liu, Hang Zhang, Zhaoyu Li, Jingjing Zhang, Haolong Zhang

Abstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhongwen ZhangSchool of Public Health, Gansu University of Chinese Medicine, Lanzhou, Gansu Province, China.
Yufei YangSchool of Public Health, Gansu University of Chinese Medicine, Lanzhou, Gansu Province, China.
Mengzhen LiuSchool of Public Health, Gansu University of Chinese Medicine, Lanzhou, Gansu Province, China.
Hang ZhangClinical College of Traditional Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu Province, China.
Zhaoyu LiCollege of Acupuncture-Moxibustion and Tuina, Gansu University of Chinese Medicine, Lanzhou, Gansu Province, China.
Jingjing ZhangFuwai Yunnan Hospital, Chinese Academy of Medical Sciences, Affiliated Cardiovascular Hospital of Kunming Medical University, Kunming, China.
Haolong ZhangClinical College of Traditional Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-coding RNAs (ncRNAs) are involved in the occurrence, progression, and repair of cardiovascular disease By post-transcriptional regulation, epigenetic modification, cell-fate determination, and metabolic homeostasis-related pathways, microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) regulate the development of atherosclerosis heart failure and hypertension The stability in circulation and cell type-specific expression of these molecules have important implications for early disease detection, risk stratification, and prognostic prediction. The development of more sensitive detection techniques facilitates accurate quantification of ncRNAs in different sources including exosomes, plasma or tissues and promotes translational research. Interventions directed toward the regulation of ncRNAs, such as miRNA inhibition or replacement and modulation of lncRNAs and circRNAs are being developed. Despite existing challenges related to ncRNA delivery, specificity, and methodological standardization, ncRNAs represent promising molecular signatures for personalized medicine. Integrated use of multi-omics, clinical phenotypes and computational algorithms is anticipated to optimize an ncRNA-guided precision management pipeline from diagnosis to prediction and treatment.

Indexed as

biomarkerscardiovascular diseaseindividualized therapymolecular regulationnon-coding RNAprecision medicine

Identifiers

PMID42831220
PMCPMC13634616

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.