Evidence map›Paper›PMID 42831214›Full record

ArticleAdvances in radiation oncology2026

Food Insecurity and Overall Survival in Locally Advanced Breast Cancer Patients Receiving Comprehensive Nodal Irradiation: The Food Insecurity-Obesity Paradox.

Austin D Thompson, Lei Hugh Dominic Escobal, Matthew Mathai, Gurbani Singh, Sravya Koduri, Matthew J Ferris, Sally Cheston, Akshar Patel, Sarah McAvoy, Elizabeth Nichols and 5 more

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Article in Advances in radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Austin D ThompsonDepartment of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland.
Lei Hugh Dominic EscobalUniversity of Maryland School of Medicine, Baltimore, Maryland.
Matthew MathaiUniversity of Maryland School of Medicine, Baltimore, Maryland.
Gurbani SinghDepartment of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
Sravya KoduriDepartment of Radiation Oncology, NYU Langone Health, New York City, New York.
Matthew J FerrisDepartment of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland.
Sally ChestonDepartment of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland.
Akshar PatelUniversity of Maryland Radiation Oncology at the Tate Cancer Center, Glen Burnie, Maryland.
Sarah McAvoyDepartment of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland.
Elizabeth NicholsDepartment of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland.
Wendla CitronUniversity of Maryland Radiation Oncology at the Tate Cancer Center, Glen Burnie, Maryland.
Sara DudleyUniversity of Maryland Upper Chesapeake Medical Center KCC Radiation Oncology, Bel Air, Maryland.
Søren M BentzenDepartment of Epidemiology and Public Health, Biostatistics and Bioinformatics Division, University of Maryland School of Medicine, Baltimore, Maryland.
Amber S KlecknerGreenbaum Comprehensive Cancer Center, University of Maryland, Maryland.
Melissa A L VyfhuisDepartment of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Residents of food-insecure areas (FIAs) experience worse cancer outcomes, but underlying mechanisms remain poorly understood. Prior studies have not determined whether inequalities result from differences in cancer characteristics, treatment delivery, adherence, or food insecurity (FI) itself. We hypothesized that patients with locally advanced breast cancer (LABC) residing in FIAs would demonstrate worse overall survival (OS) despite receiving similar cancer treatments with comparable treatment adherence. Methods and Materials: This retrospective study analyzed 943 patients with LABC treated with comprehensive nodal irradiation from 2016 to 2023. χ Results: Median follow-up was 25.0 months for non-FIA and 28.8 months for FIA residents. FIA residents (n = 60; 6.4%) were more likely to identify as Black ( Conclusions: Patients with LABC residing in FIAs had a 5.5 times higher mortality risk despite similar cancer characteristics, treatments, and adherence. Higher obesity rates among FIA residents that increased following treatment represent a novel characterization of the FI-obesity paradox in patients with breast cancer. These findings support residence in an FIA as an independent predictor of mortality and suggest that interventions must address nutritional quality and access.

Identifiers

PMID42831214
PMCPMC13634563

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.