ArticleAmerican heart journal plus : cardiology research and practice2026
Public availability of trial-design and clinical-context information in contemporary lipoprotein(a)-targeted cardiovascular trials: A cross-sectional meta-research study.
Article in American heart journal plus : cardiology research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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Authors and funding
4 authors.
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Abstract
Background: Direct lipoprotein(a) [Lp(a)]-lowering therapies are advancing toward cardiovascular outcomes testing, but the amount of publicly available trial-design and clinical-context information varies across development stages. Objective: To characterize contemporary patient-enrolling direct Lp(a)-targeted pharmacologic trials and describe fixed-date public availability of predefined trial information. Methods: We conducted a cross-sectional meta-research study anchored in ClinicalTrials.gov with linked public protocols, statistical analysis plans, design/baseline reports, supplements, and peer-reviewed manuscripts available through May 2, 2026. Contemporary trials started on or after January 1, 2017. Two reviewers independently abstracted 12 prespecified public-information elements. Elements were classified as publicly identified or not publicly identified; no composite score or trial ranking was used. Results: Fourteen trials met inclusion criteria, representing 5 agents, 3 therapeutic platforms, and 56,983 planned or reported participants. Seven trials had Lp(a) biomarker primary endpoints, 5 had clinical cardiovascular outcomes, 1 assessed apheresis burden, and 1 assessed calcific aortic valve stenosis progression. Seven trials were published/protocol-supported and 7 registry-only. Cardiovascular/risk phenotype, prevention or special-population setting, and geographic scope were identified in all trials. Other elements were identifiable less consistently: Lp(a) unit (13/14), background lipid-lowering therapy (9/14), numeric Lp(a) threshold (8/14), PCSK9/inclisiran handling (8/14), demographic information (8/14), CKD/eGFR criteria (6/14), heart failure criteria (6/14), diabetes criteria (5/14), and LDL-C context (3/14). Conclusions: Public availability varied across contemporary Lp(a)-targeted trials at the data lock, particularly for registry-only programs. These findings describe fixed-date public retrievability and should not be interpreted as protocol deficiency, registry noncompliance, trial quality, efficacy, safety, or regulatory readiness.
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