Evidence map›Paper›PMID 42831165›Full record

ArticleBioactive materials2027

Matrix nanoalignment programs macrophage vesicular immunity through TRPV2 mechanogating.

Bohan Yin, Guangli Xiang, Ziqi Zhang, Limeng Zheng, Runyao Wang, Qin Zhang, Yingying Huang, Chenjie Liu, Jingjing Chi, Xinyue Xia and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Bohan YinSchool of Medicine and Pharmacy, Ocean University of China, Qingdao, 266100, China.
Guangli XiangSchool of Medicine and Pharmacy, Ocean University of China, Qingdao, 266100, China.
Ziqi ZhangSchool of Medicine and Pharmacy, Ocean University of China, Qingdao, 266100, China.
Limeng ZhengSchool of Medicine and Pharmacy, Ocean University of China, Qingdao, 266100, China.
Runyao WangSchool of Medicine and Pharmacy, Ocean University of China, Qingdao, 266100, China.
Qin ZhangDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, 999077, China.
Yingying HuangDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, 999077, China.
Chenjie LiuSchool of Medicine and Pharmacy, Ocean University of China, Qingdao, 266100, China.
Jingjing ChiSchool of Medicine and Pharmacy, Ocean University of China, Qingdao, 266100, China.
Xinyue XiaDepartment of Physics, The Chinese University of Hong Kong, Hong Kong, 999077, China.
Jiaxiang YanDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, 999077, China.
Jianfang WangDepartment of Physics, The Chinese University of Hong Kong, Hong Kong, 999077, China.
Mo YangDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, 999077, China.
Liming BianSchool of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, 511442, China.
Siu Hong Dexter WongSchool of Medicine and Pharmacy, Ocean University of China, Qingdao, 266100, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The extracellular matrix (ECM) undergoes extensive architectural remodeling during tumor progression, generating nanoscale alignment cues that profoundly influence behaviors of immune cells. However, whether ECM nanoarchitecture directly programs their immune secretory functions remains poorly defined. Here, we develop a magnetically switchable hydrogel that enables reversible, on-demand modulation of nanoscale ligand alignment without altering bulk stiffness or composition. Using this platform, we uncover a mechanotransduction pathway in tumor-associated macrophages (TAMs) whereby matrix nanoalignment enhances integrin β1-dependent mechanosensing and transient receptor potential cation channel subfamily V member 2 (TRPV2)-dependent Ca

Indexed as

ECM nanoarchitectureMagnetic controlMechanobiologySmall extracellular vesicle releaseTumor-associated macrophages

Identifiers

PMID42831165
PMCPMC13634591

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.