Evidence map›Paper›PMID 42831162›Full record

ReviewGastro hep advances2026

CYP2D6 Metabolizer Status Does Not Predict Response or Tolerability of Low-Dose Nortriptyline for Irritable Bowel Syndrome With Diarrhea.

Kyle Staller, Jenna Clukey, Elizabeth N Madva, Brian C Healy, Minyi Lee, Manish K Gala

Abstract readReview
In one paragraph

Review in Gastro hep advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kyle StallerDivision of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Jenna ClukeyDivision of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Elizabeth N MadvaHarvard Medical School, Boston, Massachusetts.
Brian C HealyHarvard Medical School, Boston, Massachusetts.
Minyi LeeDivision of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Manish K GalaDivision of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.

Funding

Pathogenic Germline Mutations in Barrett's EsophagusR01DK137971 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Manish Gala · 2024 to 2026
$1.9M
The Role of Fiber in the Etiopathogenesis of Fecal IncontinenceK23DK120945 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI STALLER, KYLE · 2020 to 2024
$1.0M
NIDDK NIH HHS K23 DK120945NIDDK NIH HHS R01 DK137971
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID42831162
PMCPMC13634428

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.