ArticleKidney medicine2026
Effects of Lanthanum Carbonate on Whole-Body Phosphorus and Calcium Balance in Adults With Chronic Kidney Disease and Normophosphatemia.
Article in Kidney medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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10 authors.
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Abstract
Rationale & Objective: Greater serum phosphorus is associated with cardiovascular disease in those with chronic kidney disease (CKD). However, the utility of phosphorus lowering in nondialysis-requiring CKD is not clear. The effects of noncalcium-based phosphate binders on phosphorus and calcium balance in nondialysis-requiring CKD are unknown. Our objective was to determine phosphorus and calcium balance in normophosphatemic adults with CKD 3b-4 after 12 weeks of treatment with lanthanum carbonate or placebo. Study Design: Prospective, randomized, controlled, double-blind clinical trial. Setting & Participants: A subset of 15 adults with CKD 3b-4 and serum phosphorus levels within normal limits who participated in a 12-week parallel-arm, randomized controlled trial of lanthanum carbonate compared with placebo on vascular function participated in this study extension. Intervention: At the end of 12 weeks, the subset of participants consumed a controlled diet (1,000 mg/day phosphorus and 800 mg/day calcium) for 9 days and continued their randomly assigned study drug (N = 7 lanthanum carbonate, N = 8 placebo). Fasting morning blood samples and all stool and urine were collected during a 48-hour inpatient clinical research center stay at the end of the 9-day controlled diet period. Outcomes: Phosphorus and calcium balance (mg/d) were determined by values averaged over the 48 hours inpatient clinical research center admission. Results: Mean age was 65 ± 8 (SD) years, and mean estimated glomerular filtration rate was 38 ± 14 (SD) mL/min/1.73m Limitations: Small sample size. Conclusions: Twelve weeks of treatment with the noncalcium-based phosphate binder, lanthanum carbonate, may reduce whole-body phosphorus balance as well as calcium balance among adults with stage 3b-4 CKD and normophosphatemia. Whether reduced phosphorus balance or calcium balance with lanthanum carbonate is associated with beneficial clinical outcomes in CKD warrants further investigation.
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