Evidence map›Paper›PMID 42831067›Full record

ArticleJVS-vascular science2026

Elena Streck, Manuela Harloff, Dennis Freuer, Sebastian Dintner, Dimitrios Dedegkikas, Dominik Jost, Elisabeth Kling, Bruno Märkl, Martin Trepel, Alexander Hyhlik-Dürr and 1 more

Abstract read
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In one paragraph

Article in JVS-vascular science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Elena StreckDepartment of Vascular Surgery, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Manuela HarloffDepartment of Pathology, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Dennis FreuerInstitute of Epidemiology, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Sebastian DintnerDepartment of Pathology, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Dimitrios DedegkikasDepartment of Vascular Surgery, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Dominik JostDepartment of Vascular Surgery, Endovascular Surgery, and Vascular Medicine, Elisabethen-Klinikum, Ravensburg, Germany.
Elisabeth KlingInstitute for Laboratory Medicine and Microbiology, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Bruno MärklDepartment of Pathology, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Martin TrepelDepartment of Hematology and Oncology, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Alexander Hyhlik-DürrDepartment of Vascular Surgery, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Rainer ClausDepartment of Pathology, Faculty of Medicine, University of Augsburg, Augsburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Clonal hematopoiesis of indeterminate potential (CHIP), defined by somatic mutations in hematopoietic cells, is associated with cardiovascular disease through proinflammatory mechanisms. We investigated whether CHIP, and specifically Methods: In this multicenter, retrospective cohort pilot study, 47 patients with peripheral arterial disease who had undergone femoropopliteal or femorocrural bypass grafting were analyzed. CHIP status was assessed from peripheral blood using a 40-gene myeloid sequencing panel. Time-to-event analyses were performed using Kaplan-Meier survival analysis and multivariable Cox proportional hazards regression adjusted for diabetes and smoking status. Results: Of 47 patients, 33 had bypass graft occlusion and 14 had patent grafts. CHIP was detected in 14 individuals (29.8%). The mutational spectrum differed markedly between groups: in the patent graft group, all CHIP mutations were in Conclusions: Clinical relevance: Clonal hematopoiesis, particularly

Indexed as

CHIPClonal hematopoiesisGraft patencyPeripheral arterial diseasePeripheral vascular bypass occlusionTET2

Identifiers

PMID42831067
PMCPMC13634526

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.