ArticleInfection and drug resistance2026
Polymicrobial and ESBL-Producing Bacterial Infections Among Pyogenic Liver Abscess: A 12-Year Study of Risk Factors and Antimicrobial Susceptibility.
Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Pyogenic liver abscess (PLA) is a potentially life-threatening hepatic infection. The increasing prevalence of polymicrobial infections and multidrug-resistant (MDR) pathogens, including extended-spectrum β-lactamase (ESBL)-producing bacteria, poses challenges to treatment and association with higher mortality rates. Identifying risk factors and optimizing clinical management strategies for these infections are essential to improving patient outcomes. Methods: This retrospective study analyzed the clinical data of 643 PLA patients admitted in recent 12 years. Univariate and multivariate analyses were conducted to analyze treatment strategies, disease burden, and clinical outcomes, as well as identify risk factors associated with polymicrobial infections and ESBL-producing bacterial strains. Results: In this study, 255 of 643 PLA patients with positive bacterial identification were enrolled. Among them, 41 had polymicrobial infections. Of the 162 patients who underwent ESBL testing, 128 were infected with ESBL-producing bacteria. Polymicrobial PLA was significantly associated with intra-abdominal trauma or surgery (odds ratio [OR] = 3.06), malignancies or hematological diseases (OR = 3.01). ESBL-producing bacterial PLA was correlated with hepatic tenderness (OR = 3.24), intra-abdominal trauma or surgery (OR = 3.06), and hospitalization within the past three months (OR = 4.32). Conclusion: Patients with PLA who have a history of intra-abdominal trauma or surgery, malignancies or hematological diseases, and recent hospitalization should be closely monitored for polymicrobial and drug-resistant infections. Given the high prevalence of antibiotic-resistant
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