ArticleInfection and drug resistance2026
Evaluation of Brucella IgM and IgG ELISA Responses in Relation to Blood Culture Positivity in Pediatric Brucellosis.
Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Class-specific Brucella IgM and IgG enzyme-linked immunosorbent assay (ELISA) responses according to blood culture status are incompletely characterized in children with confirmed brucellosis. We compared IgM and IgG ELISA findings according to contemporaneous blood culture status among children already classified as having confirmed acute brucellosis; diagnostic accuracy was not assessed. Methods: This retrospective, single-center, cross-sectional observational study included 94 children aged 18 years or younger. Rose Bengal testing, standard tube agglutination testing (STAT), Brucella IgM and IgG ELISA, and blood culture were obtained at the same presentation. Serologic findings were compared by culture status, and factors associated with culture positivity were explored using multivariable logistic regression. Results: Blood cultures yielded Conclusion: Among children with confirmed acute brucellosis, IgM ELISA was positive in nearly all patients, while continuous IgG values were lower in culture-positive children. These findings describe associations with contemporaneous culture status and should not be interpreted as antibody kinetics or diagnostic-performance estimates. ELISA values should not be used alone to predict blood culture positivity or determine whether blood culture should be obtained.
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