Evidence map›Paper›PMID 42830919›Full record

ArticleiScience2026

Procedural circulatory support-enabled intracoronary cell delivery in advanced dilated cardiomyopathy.

Rohini Ramaseshan, Mohsin Hussain, Dhanuka Perera, Stephen Hamshere, Matthew Kelham, Pedro Pinto, James R Whiteford, Thomas C Moseley, Alice Reid, Sonia Bastos and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Rohini RamaseshanCentre for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University of London, London, UK.
Mohsin HussainUniversity Hospitals Dorset NHS Foundation Trust, Bournemouth, UK.
Dhanuka PereraCentre for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University of London, London, UK.
Stephen HamshereCentre for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University of London, London, UK.
Matthew KelhamCentre for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University of London, London, UK.
Pedro PintoDepartment of Cardiology, Barts Heart Centre, Barts Health NHS Trust, London, UK.
James R WhitefordWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Thomas C MoseleyWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Alice ReidCentre for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University of London, London, UK.
Sonia BastosDepartment of Cardiology, Barts Heart Centre, Barts Health NHS Trust, London, UK.
Jessry RussellGenes and Health, Queen Mary University of London, London, UK.
Mervyn AndiapenDepartment of Cardiology, Barts Heart Centre, Barts Health NHS Trust, London, UK.
Lucinda WynneDepartment of Cardiology, Barts Heart Centre, Barts Health NHS Trust, London, UK.
Ceri DaviesDepartment of Cardiology, Barts Heart Centre, Barts Health NHS Trust, London, UK.
Thomas KeebleEssex Cardiothoracic Centre, Basildon, UK.
Samer FawazEssex Cardiothoracic Centre, Basildon, UK.
John MartinUniversity College London, London, UK.
Cono AritiCentre for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University of London, London, UK.
Daniel A JonesCentre for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University of London, London, UK.
Anthony MathurCentre for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University of London, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advanced heart failure due to dilated cardiomyopathy (DCM) has limited treatment options. Although intracoronary autologous cell therapy may improve cardiac function, its use in patients with severe left ventricular dysfunction is limited by procedural risk. This exploratory study investigated whether temporary mechanical circulatory support with an Impella device could enable safer therapy delivery. Twenty patients with DCM and a left ventricular ejection fraction (LVEF) of ≤35% received granulocyte colony-stimulating factor pretreatment followed by Impella-supported intracoronary infusion of autologous bone marrow mononuclear cells. The procedure was feasible, well tolerated, and not associated with major complications. After three months, mean LVEF increased by 2.9%, with numerically greater gains in those with more severe baseline impairment. Participants also experienced symptomatic, exercise capacity, and quality of life improvements. Changes in microvascular function and circulating soluble receptor for advanced glycation end-products (sRAGE) suggested potential mechanistic pathways. As a single-arm study, these findings are hypothesis generating and support further evaluation in randomized controlled trials.

Indexed as

cell therapycirculatory supportclinical trialdilated cardiomyopathyheart failure

Identifiers

PMID42830919
PMCPMC13634339

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.