ArticleOphthalmology science2026
Sex-Specific Differences in Corneal Remodeling after Descemet Membrane Endothelial Keratoplasty in Fuchs Endothelial Corneal Dystrophy.
Article in Ophthalmology science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective/Purpose: To evaluate sex-specific differences in preoperative disease severity and postoperative outcomes, including endothelial cell count (ECC), central corneal thickness (CCT), peripheral corneal thickness (PCT), and visual acuity, in patients with Fuchs endothelial corneal dystrophy (FECD) undergoing Descemet membrane endothelial keratoplasty (DMEK). Design: Retrospective, single-center cohort study. Participants/Subjects: Of the 181 eyes screened, 144 eyes (95 women, 49 men) with FECD undergoing DMEK at a tertiary referral center met the inclusion criteria of complete clinical data and ≥12 months of postoperative follow-up. Main Outcome Measures: Best spectacle-corrected visual acuity (BSCVA, logarithm of the minimum angle of resolution), ECC, CCT, and PCT assessed preoperatively and at 1, 3, 6, and 12 months postoperatively. Results: Mean (standard deviation) age at surgery was 72.8 (9.6) years in women and 70.9 (10.1) years in men (P = 0.25). Preoperatively, men had lower ECC (1466 ± 362 vs. 1729 ± 370 cells/mm²; Conclusions: Men with FECD exhibited more pronounced preoperative structural corneal changes and greater PCT after DMEK despite comparable visual recovery. Biological sex remained independently associated with postoperative PCT, but not ECC, after adjustment. These findings suggest sex-specific differences in FECD structural manifestations and postoperative corneal remodeling and warrant validation in prospective multicenter studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.