Evidence map›Paper›PMID 42830894›Full record

ArticleMedComm2026

A State-Resolved Single-Cell and Spatial Atlas Reveals

Ashraf Zaman, Emily Holton, Madhavi Pandya, Genevieve Shillington, Cecile Escher, Kavitha Krishna Sudhakar, Agota Tuzesi, Ashish Mehta, Eric Lam, Rachael Zekanovic and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ashraf Zaman *Translational Genomics Program, Garvan Institute of Medical Research Sydney Australia.
Emily Holton *Translational Genomics Program, Garvan Institute of Medical Research Sydney Australia.
Madhavi PandyaTranslational Genomics Program, Garvan Institute of Medical Research Sydney Australia.
Genevieve ShillingtonTranslational Genomics Program, Garvan Institute of Medical Research Sydney Australia.
Cecile EscherTranslational Genomics Program, Garvan Institute of Medical Research Sydney Australia.
Kavitha Krishna SudhakarTranslational Genomics Program, Garvan Institute of Medical Research Sydney Australia.
Agota TuzesiTranslational Genomics Program, Garvan Institute of Medical Research Sydney Australia.
Ashish MehtaTranslational Genomics Program, Garvan Institute of Medical Research Sydney Australia.
Eric LamTranslational Genomics Program, Garvan Institute of Medical Research Sydney Australia.
Rachael ZekanovicTranslational Genomics Program, Garvan Institute of Medical Research Sydney Australia.
Michael SughrueOmniscient Neurotechnology Sydney Australia.
Charlie TeoCingulum Health Clinic Sydney Australia.
Jacky YeungYale School of Medicine New Haven USA.
Walter MuskovicTranslational Genomics Program, Garvan Institute of Medical Research Sydney Australia.
Joseph E PowellTranslational Genomics Program, Garvan Institute of Medical Research Sydney Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adult-type diffuse gliomas are defined by the isocitrate-dehydrogenase (IDH) axis, yet how this biology constrains malignant cell-state repertoires and their immune-modulatory potential remains unclear. We profiled 69 tumors using single-cell RNA sequencing (scRNA-seq), single-nucleus RNA sequencing (snRNA-seq), and spatial transcriptomics, and resolved seven recurrent malignant cell states: astrocyte-like progenitor cells (ALPC), hypoxia, cycling G1/S, cycling G2/M, oligo-lineage, neuro-oligo-lineage, and neuro-lineage. The

Indexed as

astrocyte‐like progenitor cells (ALPC)diffuse gliomasingle‐cell RNA sequencingspatial transcriptomicstranscriptional heterogeneity

Identifiers

PMID42830894
PMCPMC13634174

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.