Evidence map›Paper›PMID 42830759›Full record

ArticleJournal of orthopaedic translation2026

Exercise alleviates age-related osteoarthritis associated with PGC-1α activation to suppress chondrocyte senescence and aberrant glycolysis.

Yuting Cao, An Lao, Shijie Zhu, Fangchun Jin, Zhou Sha, Yu Zhuang, Huilu Zhan, Liao Wang, Huiwu Li, Kaili Lin and 1 more

Abstract read
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In one paragraph

Article in Journal of orthopaedic translation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuting CaoShanghai YangZhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai 200092, China.
An LaoDepartment of Oral and Cranio-maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China.
Shijie ZhuShanghai YangZhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai 200092, China.
Fangchun JinDepartment of Pediatric Orthopedics, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Yangpu District, 1665 Kong jiang Road, Shanghai 200092, China.
Zhou ShaShanghai YangZhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai 200092, China.
Yu ZhuangDepartment of Oral and Cranio-maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China.
Huilu ZhanDepartment of Oral and Cranio-maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China.
Liao WangShanghai Key Laboratory of Orthopedic Implants, Clinical and Translational Research Center for 3D Printing Technology, Shanghai Frontiers Science Center of Degeneration and Regeneration in Skeletal System, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Huiwu LiShanghai ninth people's hospital, Shanghai jiaotong university school of medicine, 200011, China.
Kaili LinDepartment of Oral and Cranio-maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China.
Rui ZhuShanghai YangZhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai 200092, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Age-related osteoarthritis (OA) is a leading global disability cause. Exercise is recommended as first-line therapy but poorly tolerated by elderly patients. This study elucidated the mechanism of low-intensity exercise in OA and develop a targeted exercise-mimetic nanotherapy. Methods: The effects of low-intensity swimming exercise on age-related OA were investigated using aged mouse models. A senescence-targeted nanoparticle system (NP-B2M) was fabricated via a double-emulsion solvent evaporation method combined with EDC/NHS conjugation. The mechanisms underlying exercise and PGC-1α-mediated metabolic reprogramming were explored using transcriptomic sequencing, glycolysis analysis, RT-qPCR, and Western blotting in IL-1β-induced senescent ATDC5 chondrocytes. The therapeutic efficacy of intra-articular delivery of NP-B2M was systematically evaluated using micro-CT, histological staining, and immunohistochemistry in aged mice. Results: Low-intensity swimming attenuated OA by suppressing chondrocyte senescence and pathological glycolysis via activating PGC-1α, effects that were recapitulated by ZLN005. NP-B2M enabled targeted intra-articular drug release and showed superior efficacy over free ZLN005. Conclusion: This study demonstrates that low-intensity exercise alleviates age-related OA via PGC-1α-mediated metabolic reprogramming. NP-B2M provides a biocompatible, precisely targeted, long-acting platform that mimics exercise benefits, offering promising translational potential as a precision therapeutic strategy for immobile elderly OA patients. The translational potential of this article: In this study, we developed NP-B2M, a PLGA-based nanoplatform, achieves prolonged joint retention and enhanced efficacy versus free drug, representing a promising targeted approach for OA patients with limited mobility.

Indexed as

Chondrocyte senescenceGlycolytic reprogrammingOsteoarthritisPGC-1αSenescence-targeted nanoparticle

Identifiers

PMID42830759
PMCPMC13634101

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.