ArticleCurrent research in parasitology & vector-borne diseases2026
The spread of pyrethroid-resistant mosquitoes and their predicted malaria burden across the Democratic Republic of the Congo.
Article in Current research in parasitology & vector-borne diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malaria control in the Democratic Republic of the Congo (DRC) is increasingly challenged by pyrethroid resistance in mosquito populations, although its epidemiological consequences remain uncertain. Entomological data from discriminating-dose bioassays conducted on wild mosquitoes were collated to characterise temporal changes in pyrethroid resistance since 2009. These estimates were incorporated into a mechanistic malaria transmission model to quantify how resistance may have reduced the effectiveness of insecticide-treated nets (ITNs) and affected malaria burden. Model projections were compared with malaria prevalence estimates from the 2013-2014 and 2023-2024 Demographic and Health Surveys, which were used as external comparisons rather than for model fitting. Counterfactual scenarios were generated in which mosquitoes remained fully susceptible to pyrethroids throughout the study period. The model estimated that pyrethroid resistance increased substantially over time and reduced the protection provided by pyrethroid-only ITNs. Nationally, approximately 8.6% of malaria clinical cases, corresponding to 33.6 million additional cases, and approximately 76,000 additional deaths between 2009 and 2024 were attributable to pyrethroid resistance in the modelled counterfactual comparison. The introduction of pyrethroid-PBO ITNs from 2019 partially restored the protection lost to pyrethroid resistance. These findings highlight the potential epidemiological consequences of pyrethroid resistance while also emphasising the uncertainty arising from sparse resistance surveillance and limited epidemiological observations. Improved entomological surveillance and continued deployment of more effective vector-control tools will be important for malaria control in the DRC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.