Evidence map›Paper›PMID 42830745›Full record

ArticleCritical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine2026

Persistent lymphopaenia in critically ill patients with and without sepsis: An Australian and New Zealand point prevalence study.

Derick Adigbli, Anthony Devaux, Serena Knowles, Miranda Hardie, Chris Gianacas, Balasubramanian Venkatesh, Naomi Hammond, Simon Finfer, Australian and New Zealand Intensive Care Society Point Prevalence Program and The George Institute for Global Health

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Article in Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Derick AdigbliDepartment of Intensive Care, Austin Health, Heidelberg, VIC, Australia.
Anthony DevauxUniversity of New South Wales, Sydney, NSW, Australia.
Serena KnowlesCritical Care Program, The George Institute for Global Health, Faculty of Medicine and Health, UNSW Sydney, Randwick, NSW, Australia.
Miranda HardieCritical Care Program, The George Institute for Global Health, Faculty of Medicine and Health, UNSW Sydney, Randwick, NSW, Australia.
Chris GianacasUniversity of New South Wales, Sydney, NSW, Australia.
Balasubramanian VenkateshUniversity of New South Wales, Sydney, NSW, Australia.
Naomi HammondUniversity of New South Wales, Sydney, NSW, Australia.
Simon FinferUniversity of New South Wales, Sydney, NSW, Australia.
Australian and New Zealand Intensive Care Society Point Prevalence Program and The George Institute for Global Health

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The aim of this study was to determine the prevalence of persistent lymphopaenia, defined as an absolute lymphocyte count (ALC) < 1.0 × 10 Design setting and participants: A prospective, multicentre, binational point prevalence study of adult patients treated in participating ICUs in June 2023 was conducted. Main outcome measures: Main outcome measures included prevalence of persistent lymphopaenia in patients with sepsis versus those without sepsis, hospital and ICU mortality, length of stay, and organ support patterns. Results: Among 829 adult patients in 59 ICUs, 307 (37%) had persistent lymphopaenia, and 338 (40.8%) met sepsis criteria. Persistent lymphopaenia was associated with greater illness severity (mean Acute Physiology and Chronic Health Evaluation II score: 19.4 vs. 16.8, Conclusion: Persistent lymphopaenia is common in critically ill patients, particularly those with sepsis. Future prospective and interventional investigations are required to clarify the clinical significance of persistent lymphopaenia in critically ill adults and its potential as a therapeutic target.

Indexed as

ImmunosuppressionLymphocyteMortalitySepsis

Identifiers

PMID42830745
PMCPMC13633860

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.