ArticleSkin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)2026
Correlation Study of Subjective Clinical Evaluation and Skin Biophysical Properties in Facial Skin among Young Korean Women; Pilot Study.
Article in Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAlthough standardized, evidence-based diagnostic tools are essential for the assessment of the efficacy of facial skin rejuvenation, aesthetic medicine has largely relied on subjective evaluations, especially in primary clinics. Recent studies have demonstrated the potential of skin biophysical properties for objective assessment; however, they are not widely applied in clinical practice.
aimsTo investigate the correlation of physicians' clinical evaluations of skin hydration, skin firmness, melanin, and erythema with skin biophysical properties. PATIENTS/
methodsTwenty Korean women with healthy skin were clinically and quantitatively evaluated. The former comprised questionnaires with 7-point scales regarding the grade of skin hydration, firmness, melanin, and erythema, completed by a dermatologist; the latter comprised measurements of conductance, trans-epidermal water loss (TEWL), gross elasticity (R2), dermal thickness, and melanin and erythema by another physician independently to subjective assessment.
resultsConductance and TEWL were significantly correlated with subjective hydration scores (Spearman's 𝜌 = 0.456 and 𝜌 = -0.604, respectively). Moreover, the objectively measured melanin index demonstrated a significant positive correlation with the clinically assessed melanin severity score (𝜌 = 0.612, p < 0.01). Clinical evaluation of erythema was significantly correlated with Young's modulus (𝜌 = -0.614) and inversely correlated with dermal thickness (𝜌 = 0.781, both p < 0.01).
conclusionsUnlike skin hydration, melanin, and erythema, skin firmness did not significantly correlate with biophysical properties. Thus, clinical evaluation is insufficient to establish treatment strategies for skin tightening in young women. Quantitative data may be an effective adjunctive diagnostic tool for patients who require subclinical interventions. This study was pilot study to explore the potential of objective measurements as adjunctive diagnostic tool in clinical setting, while some limitations include a small sample size, narrow range of age, and sex bias.
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