Evidence map›Paper›PMID 42830485›Full record

ArticleGenes to cells : devoted to molecular & cellular mechanisms2026

A YAP-TEAD-CTCF Transcriptional Regulatory Axis Associated With the Elimination of Injured Hepatocytes From the Liver.

Daiki Hatakeyama, Yoshimi Okamoto-Uchida, Misaki Kosaka, Haruka Hirose, Satoshi Kofuji, Keiko Danzaki, Yoshiki Endo, Michiko Nakagawa, Akinori Kanai, Yutaka Suzuki and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes to cells : devoted to molecular & cellular mechanisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Daiki HatakeyamaMedical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Tokyo, Japan.
Yoshimi Okamoto-UchidaMedical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0001-9887-3114
Misaki KosakaMedical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Tokyo, Japan.ORCID https://orcid.org/0009-0005-9081-0350
Haruka HiroseMedical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Tokyo, Japan.
Satoshi KofujiMedical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0003-1384-8425
Keiko DanzakiMedical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Tokyo, Japan.
Yoshiki EndoMedical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Tokyo, Japan.
Michiko NakagawaMedical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Tokyo, Japan.
Akinori KanaiGraduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan.ORCID https://orcid.org/0000-0003-1555-6768
Yutaka SuzukiGraduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan.ORCID https://orcid.org/0000-0003-4852-1879
Takeshi YokooDivision of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Health Sciences, Niigata University, Niigata, Japan.ORCID https://orcid.org/0000-0001-7138-1785
Shuji TeraiDivision of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Health Sciences, Niigata University, Niigata, Japan.ORCID https://orcid.org/0000-0002-5439-635X
Teppei ShimamuraMedical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Tokyo, Japan.
Hiroshi NishinaMedical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0002-6647-7480

Funding

Japan Agency for Medical Research and Development JP22-24fk0310508Japan Society for the Promotion of Science JP22H04925Japan Society for the Promotion of Science JP23K06628Japan Society for the Promotion of Science JP24K02177Japan Society for the Promotion of Science JP26K10125Multilayered Stress Diseases JPMXP1323015483Nanken-Kyoten, Science TokyoPharmacodynamics Research FoundationPriority Research Areas in Medical and Dental SciencesSecom Science and Technology FoundationYoung Innovative Medical Scientist Unit
6 · The paper itself

Abstract

The liver maintains tissue homeostasis both by undergoing regeneration and by eliminating abnormal or injured hepatocytes. The transcriptional coactivator YAP in collaboration with the TEAD family of transcription factors regulates hepatocyte proliferation. It has also been associated with injured hepatocyte elimination whereby YAP-active injured hepatocytes are extruded into the sinusoidal lumen and undergo cell death followed by macrophage phagocytosis. However, the molecular mechanisms underlying this process are unknown. To address this, we performed RNA-seq analysis in YAP-active injured hepatocytes that are eliminated from the liver. We found increased expression of multiple genes associated with cell cycle arrest and cytoskeletal remodeling. Ligand-receptor analysis using single-cell spatial transcriptomics showed that YAP-active hepatocytes express the secreted factors CSF1 and CCL2, which promote macrophage recruitment and activation. ATAC-seq analysis in YAP-active hepatocytes revealed a significant increase in chromatin accessibility at regions containing CTCF-binding motifs, and the YAP-TEAD4 complex associated with CTCF in the nucleus. These results indicate that a YAP-TEAD-CTCF axis shapes the gene expression program underlying injured hepatocyte elimination through chromatin structural remodeling, resulting in liver homeostasis.

Indexed as

Adaptor Proteins, Signal TransducingDNA-Binding ProteinsHepatocytesLiverTranscription FactorsAnimalsCell Cycle ProteinsGene Expression RegulationMaleMiceMice, Inbred C57BLTEA Domain Transcription FactorsYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingCell Cycle ProteinsDNA-Binding ProteinsTead4 protein, mouseTEA Domain Transcription FactorsTranscription FactorsYap1 protein, mouseYAP-Signaling ProteinsCTCFhepatocyte eliminationspatial transcriptomicsTEADYAP

Identifiers

PMID42830485
PMCPMC13635467

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.