Evidence map›Paper›PMID 42830418›Full record

ArticleAnnals of clinical and translational neurology2026

Copine-4 Paraneoplastic Autoimmune Encephalitis.

Mimi S Fang, Amy Ml Quek, Clement Yong, Amir Adeli, Gabrielle N Conway, Connie E Lesnick, Diana Anissian, Divyanshu Dubey, John R Mills, Sean J Pittock and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of clinical and translational neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mimi S FangDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Amy Ml QuekDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Clement YongDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Amir AdeliNeurology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Gabrielle N ConwayMarshall University Medical Center, Huntington, West Virginia, USA.
Connie E LesnickDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Diana AnissianDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Divyanshu DubeyDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.ORCID https://orcid.org/0000-0002-4302-4075
John R MillsDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Sean J PittockDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.ORCID https://orcid.org/0000-0002-6140-5584
Anastasia ZekeridouDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.ORCID https://orcid.org/0000-0002-1960-9065
Michael GilliganDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Andrew McKeonDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.ORCID https://orcid.org/0000-0001-6856-8143

Funding

Seronegative Autoimmune Encephalopathies: Biomarker Discovery, Validation & Deep PhenotypingR01NS126227 · NINDS · MAYO CLINIC ROCHESTER · PI Andrew McKeon · 2022 to 2026
$1.9M
NINDS NIH HHS R01 NS126227NINDS NIH HHS RO1NS126227
6 · The paper itself

Abstract

We characterize copine-4 (CPNE4)-IgG and report clinical associations. Among 844 samples with unclassified neural IgGs identified by mouse-brain indirect immunofluorescence assay over 2 years, 5 samples (serum, 3; CSF, 2) from 3 patients produced a distinctive cerebrum-restricted synaptic pattern. Protein microarray disclosed CPNE4 "top hit" in those 3 patients; specificity was confirmed by 3 CPNE4-specific assays (confocal IFA, cell-based, and western blot). Median onset age was 67 years (range 60-68); all had encephalitis: a brainstem syndrome during immune checkpoint inhibitor therapy for lung cancer (2) and anti-NMDA-receptor encephalitis accompanied by neuroectoderm-lineage cancer (1). To date, CPNE4-IgG has paraneoplastic encephalitis significance.

Indexed as

brainstem encephalitisencephalitisimmune checkpoint inhibitorsparaneoplastic syndrome

Identifiers

PMID42830418
PMCPMC13635405

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.