Evidence map›Paper›PMID 42830335›Full record

ArticleNature communications2026

Trifluoroacetate mediated reduction of atherosclerosis in mice.

Wei Tang, Audrey S Black, Romana Moench, Katayoon Marzban, Juan Antonio Raygoza Garay, James J Zheng, Louis Conway, Antonio F M Pinto, Christopher G Parker, Alan Saghatelian and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wei TangDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.
Audrey S BlackDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.
Romana MoenchDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.ORCID 0000-0003-3438-3751
Katayoon MarzbanDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.
Juan Antonio Raygoza GarayDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.
James J ZhengDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.ORCID 0009-0006-2698-1515
Louis ConwayDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.ORCID 0000-0002-8448-5804
Antonio F M PintoClayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, CA, USA.
Christopher G ParkerDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.ORCID 0000-0001-8509-9289
Alan SaghatelianClayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0002-0427-563X
Luke J LemanDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.ORCID 0000-0002-1879-5900
M Reza GhadiriDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, USA. ghadiri@scripps.edu.ORCID 0000-0002-5997-9271

Funding

Managing Atherosclerosis by Modulating HDL FunctionR01HL118114 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI GHADIRI, M. REZA · 2013 to 2025
$8.5M
The Discovery of Human Peptide Encoding GenesR01GM102491 · NIGMS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI O'SHEA, CLODAGH, SAGHATELIAN, ALAN · 2012 to 2025
$5.5M
NHLBI NIH HHS R01 HL118114NIGMS NIH HHS R01 GM102491U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01GM102491U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01HL118114
6 · The paper itself

Abstract

Trifluoroacetate (TFA) has been assumed to be an innocuous counterion in countless synthetic bioactive peptides and a few FDA-approved therapeutics. Here we show that TFA is in fact bioactive, inducing peroxisome proliferation and causing significant metabolic effects in three strains of mice (wild-type C57BL/6 J, Ldlr

Indexed as

AtherosclerosisTrifluoroacetic AcidAnimalsApolipoproteins ECholesterol, LDLDiet, High-FatDisease Models, AnimalHumansLiverMaleMiceMice, Inbred C57BLMice, KnockoutPeroxisomesPPAR alphaReceptors, LDLApolipoproteins ECholesterol, LDLPPAR alphaReceptors, LDLTrifluoroacetic AcidTriglycerides

Identifiers

PMID42830335
PMCPMC13635227

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.