Evidence map›Paper›PMID 42830317›Full record

ArticleNature communications2026

Increased encoding of aversive stimuli by lateral habenula neurons during Δ

Eun-Kyung Hwang, Deborah Daphne, Charlie J Maddox, Agustin Zapata, Alexander F Hoffman, Carl R Lupica

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Eun-Kyung Hwang *National Institutes of Health, National Institute on Drug Abuse Intramural Research Program, Cellular and Neurocomputational Systems Branch, Electrophysiology Research Section, Baltimore, MD, USA.ORCID 0009-0007-8199-9133
Deborah Daphne *National Institutes of Health, National Institute on Drug Abuse Intramural Research Program, Cellular and Neurocomputational Systems Branch, Electrophysiology Research Section, Baltimore, MD, USA.
Charlie J MaddoxNational Institutes of Health, National Institute on Drug Abuse Intramural Research Program, Cellular and Neurocomputational Systems Branch, Electrophysiology Research Section, Baltimore, MD, USA.ORCID 0009-0000-6225-7467
Agustin ZapataNational Institutes of Health, National Institute on Drug Abuse Intramural Research Program, Cellular and Neurocomputational Systems Branch, Electrophysiology Research Section, Baltimore, MD, USA.
Alexander F HoffmanNational Institutes of Health, National Institute on Drug Abuse Intramural Research Program, Cellular and Neurocomputational Systems Branch, Electrophysiology Research Section, Baltimore, MD, USA.ORCID 0000-0002-2676-0628
Carl R LupicaNational Institutes of Health, National Institute on Drug Abuse Intramural Research Program, Cellular and Neurocomputational Systems Branch, Electrophysiology Research Section, Baltimore, MD, USA. clupica@intra.nida.nih.gov.ORCID 0000-0002-5375-3263

Funding

Role of the lateral habenula in impulsive behaviorZIADA000643 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI LUPICA, CARL · 2022 to 2025
$6.1M
Intramural NIH HHS ZIA DA000643U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) 1ZIADA000643
6 · The paper itself

Abstract

The lateral habenula (LHb) integrates cortical and basal forebrain (BF) input and is implicated in negative affective states, but its involvement in negative affect associated with cannabis withdrawal is unknown. Here, effects of withdrawal from the psychoactive cannabis constituent, Δ

Indexed as

DronabinolHabenulaNeuronsSubstance Withdrawal SyndromeAnimalsFeargamma-Aminobutyric AcidMaleOptogeneticsRatsRats, Sprague-DawleyDronabinolgamma-Aminobutyric Acid

Identifiers

PMID42830317
PMCPMC13635186

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.