Evidence map›Paper›PMID 42830306›Full record

ArticleNature communications2026

Structure and mechanism of HDV ribozymes revealing Lewis acid catalysis by a metal ion.

Yuhang Luo, Xiaoxue Chen, Xiaowei Lin, Wenjian Liao, Bowen Xiao, Mengxiao Li, Zhaoji Qiu, Timothy J Wilson, Zhichao Miao, Jia Wang and 2 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yuhang Luo *Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Xiaoxue Chen *Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Xiaowei Lin *Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.ORCID 0000-0002-8033-0186
Wenjian Liao *Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Bowen Xiao *Guangzhou National Laboratory, Guangzhou, China.ORCID 0009-0000-7913-4316
Mengxiao LiGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Zhaoji QiuSchool of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou, China.ORCID 0009-0000-8378-889X
Timothy J WilsonNucleic Acid Structure Research Group, The Division of Molecular, Cell and Developmental Biology, Faculty of Life Sciences, The University of Dundee, Dundee, UK.ORCID 0000-0002-3427-593X
Zhichao MiaoGuangzhou National Laboratory, Guangzhou, China.ORCID 0000-0002-5777-9815
Jia WangCollege of Pharmacy, Shenzhen Technology University, Shenzhen, China.
Lin HuangGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. huanglin36@mail.sysu.edu.cn.ORCID 0000-0002-2121-365X
David M J LilleyNucleic Acid Structure Research Group, The Division of Molecular, Cell and Developmental Biology, Faculty of Life Sciences, The University of Dundee, Dundee, UK. d.m.j.lilley@dundee.ac.uk.ORCID 0000-0001-6882-2818

Funding

Guangdong Science and Technology Department (Science and Technology Department, Guangdong Province) 2024A1515012594RCUK | Engineering and Physical Sciences Research Council (EPSRC) EP/X01567X/1
6 · The paper itself

Abstract

We have determined the molecular structure and investigated the catalytic mechanism of two ribozymes of the Hepatitis delta virus family, found in the nematode Caenorhabditis briggsae and virus Ackermannviridae. Crystal structures of both conform to the double-pseudoknot architecture adopted by the viral HDV ribozyme. The C. briggsae ribozyme has been determined both pre- and post-cleavage. In the former both nucleotides flanking the scissile phosphate are observed, along with a metal ion, and cytosine 75 N3 bound to the O5' leaving group. The pH dependence of cleavage rate reveals a pK

Indexed as

Hepatitis Delta VirusLewis AcidsMetalsRNA, CatalyticAnimalsCatalysisCrystallography, X-RayHydrogen-Ion ConcentrationModels, MolecularNucleic Acid ConformationLewis AcidsMetalsRNA, Catalytic

Identifiers

PMID42830306
PMCPMC13635239

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.