ArticleNature communications2026
Reproducible human reward imaging phenotypes exhibit differential sensitivity to dopamine D2 receptor antagonism.
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Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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45 authors.
Nicola Sambuco *Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.ORCID http://orcid.org/0000-0001-8941-1049
Antonella Lupo *Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.
Peter C T HawkinsDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-2256-1648
Pierluigi SelvaggiDepartment of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.ORCID http://orcid.org/0000-0001-9069-0700
Linda A AntonucciDepartment of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.
Alessandro BertolinoDepartment of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.
Giuseppe BlasiDepartment of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.ORCID http://orcid.org/0000-0003-0878-1131
Piergiuseppe Di PaloDepartment of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.
Luigi GrassiDepartment of Neuroscience and Rehabilitation, Institute of Psychiatry, University of Ferrara, Ferrara, Italy.ORCID http://orcid.org/0000-0002-1050-4494
Daniela GrassoDepartment of Neuroradiology, IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Foggia, Italy.
Philipp HomanPsychiatric Hospital, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0001-9034-148X
Gian Marco LeggioDepartment of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.ORCID http://orcid.org/0000-0002-7280-4871
Francesco MassariPsychiatric Unit - University Hospital, Bari, Italy.
Alessio Maria MonteleoneDepartment of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy.
Martin OsugoDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-5462-8464
Roberta PassiatoreLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID http://orcid.org/0009-0002-4355-3185
Alessandra RaioDepartment of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.
Antonio RampinoDepartment of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.ORCID http://orcid.org/0000-0002-9654-3266
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0000-0003-4595-1144
Gareth J BarkerDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-5214-7421
Arun L W BokdeDiscipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0003-0114-4914
Rüdiger BrühlPhysikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany.ORCID http://orcid.org/0000-0003-0111-5996
Sylvane DesrivièresSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-9120-7060
Herta FlorInstitute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0000-0003-4809-5398
Hugh GaravanDepartments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA.ORCID http://orcid.org/0000-0002-8939-1014
Penny GowlandSir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, United Kingdom.ORCID http://orcid.org/0000-0002-4900-4817
Antoine GrigisNeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France.
Andreas HeinzDepartment of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0001-5405-9065
Jean-Luc MartinotINSERM U1299 'Developmental Trajectories in Psychiatry and Addictology', University Paris-Saclay, Ecole Normale Supérieure Paris-Saclay, Mathematics Department, Centre Borelli CNRS, Gif-sur-Yvette, France.
Marie-Laure Paillère MartinotINSERM U1299 'Developmental Trajectories in Psychiatry and Addictology', University Paris-Saclay, Ecole Normale Supérieure Paris-Saclay, Mathematics Department, Centre Borelli CNRS, Gif-sur-Yvette, France.
Eric ArtigesINSERM U1299 'Developmental Trajectories in Psychiatry and Addictology', University Paris-Saclay, Ecole Normale Supérieure Paris-Saclay, Mathematics Department, Centre Borelli CNRS, Gif-sur-Yvette, France.ORCID http://orcid.org/0000-0003-4461-7646
Frauke NeesInstitute of Medical Psychology, Ludwig-Maximilians-Universität (LMU) in Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-7796-8234
Dimitri Papadopoulos OrfanosNeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France.ORCID http://orcid.org/0000-0002-1242-8990
Luise PoustkaDepartment of Child and Adolescent Psychiatry, Center for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany.
Michael N SmolkaDepartment of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany.ORCID http://orcid.org/0000-0001-5398-5569
Nathalie HolzDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0000-0002-6225-9267
Nilakshi VaidyaCentre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-4600-7158
Henrik WalterDepartment of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.ORCID http://orcid.org/0000-0002-9403-6121
Robert WhelanSchool of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0002-2790-7281
Gunter SchumannCentre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-7740-6469
IMAGEN Consortium
Apulian Network on Risk for Psychosis
Oliver D HowesDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-2928-1972
Mitul A MehtaDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. mitul.mehta@kcl.ac.uk.ORCID http://orcid.org/0000-0003-1152-5323
Giulio PergolaDepartment of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy. giulio.pergola@uniba.it.ORCID http://orcid.org/0000-0002-9193-1841
Funding
EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) 798181EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) 964874Roche (F. Hoffmann-La Roche Ltd) BP29001
Abstract
Human reward processing varies along cue-centric and outcome-centric axes, but the mechanistic basis of individual variation in incentive salience attribution remains incompletely characterized. Here we show, using fMRI across five cohorts (N-total = 1251; N1 = 890; N2 = 245; N3 = 34; N4 = 48; N5 = 34), two reproducible imaging phenotypes mirroring sign- and goal-tracking (ST-like, GT-like). ST-like individuals showed dominant ventral striatal responses to reward-anticipation cues and sustained incentive salience attribution; GT-like individuals showed heightened responses to reward outcomes. This distinction was replicable across sites and independent samples. Single-dose and repeated-dose D
Indexed as
Dopamine D2 Receptor AntagonistsReceptors, Dopamine D2RewardAdultAmisulprideAntipsychotic AgentsDopamine AntagonistsFemaleHaloperidolHumansMagnetic Resonance ImagingMalePhenotypeReceptors, Dopamine D3RisperidoneVentral StriatumAmisulprideAntipsychotic AgentsDopamine AntagonistsDopamine D2 Receptor AntagonistsHaloperidolReceptors, Dopamine D2Receptors, Dopamine D3Risperidone
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42830297What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.