ArticlePoultry science2026
Selection for antibody response against sheep red blood cells alters multiple chicken alloantigen allele frequencies.
Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chicken erythrocyte alloantigens were first identified using specific antisera. Recent work has developed SNP assays to identify alloantigen genes and their chromosomal location. This study's objective was to identify alloantigen systems A, B, D, E, and I variation in two pairs of lines, with different parental breed origin after multiple generations of divergent selection for antibody response against sheep red blood cells (SRBC) using allele-specific SNP assays and to compare allele frequencies across selected lines. Cornell Randombred White Leghorn founders at Virginia Tech were selected for high (VA-HAS) or low antibody (VA-LAS) response to intravenous immunization of SRBC at each generation. One hundred randomly selected generation 48 progeny were examined from each line. A second set of lines were selected from a ISA Warren medium heavy brown layer population at Wageningen University (WUR) for high (WUR-HA) or low antibody (WUR-LA) titers following subcutaneous immunization with SRBC at each generation. A random-bred control line (WUR-CON) was maintained as well. Selection generation 32, including 136 WUR-HA, 124 WUR-LA and 64 WUR-CON chickens, were tested for alloantigen genotypes. Haplotype frequencies were determined and compared between pairs of lines, using the chisq.test function in R. Lines VA-HAS and VA-LAS had 2 to 5 alleles for each alloantigen with frequencies differing significantly between the lines for all five alloantigen systems. Alloantigen B (MHC) frequencies had striking divergence with each line being nearly homozygous for alternate alleles, as reported previously. Lines WUR-HA and WUR-LA had 3 to 6 alleles for each alloantigen. Alloantigen frequencies for systems A, B, D, and E but not I differed significantly between WUR-HA and WUR-LA. The WUR-HA and WUR-LA allele frequencies differed significantly from WUR-CON, except for the D system in WUR-LA chickens. Alloantigen frequency shifts in two different breeds under similar selection protocols for the specific antibody response against SRBC suggests that alloantigens other than the B system (MHC) are associated with specific antibody response.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.