ArticlePoultry science2026
Anti-CaSR egg yolk antibody improves calcium absorption and bone mineral deposition through intestinal CaSR modulation.
Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium-sensing receptor (CaSR) is a key negative regulator of intestinal calcium transport, and targeting CaSR represents a promising strategy to improve mineral retention. Egg yolk antibodies can be used as a feed-based approach to modulate intestinal physiological processes. Therefore, this study aimed to evaluate whether anti-CaSR egg yolk antibodies could modulate intestinal calcium transport and enhance calcium and phosphorus retention in broilers. Hy-Line Brown laying hens were immunized over a 4-week period with either a CaSR peptide vaccine or an adjuvant control (without CaSR peptide). High titers of anti-CaSR antibodies were detected in egg yolk at week 5, indicating successful antibody production. The egg yolks were subsequently collected, freeze-dried into powder, and incorporated into broiler diets at a supplementation level of 0.5%. A 14-day feeding trial demonstrated that dietary supplementation with anti-CaSR antibodies markedly increased serum calcium and phosphorus levels, improved apparent ileal digestibility of both minerals, and enhanced tibial ash as well as calcium and phosphorus deposition. Mechanistically, dietary supplementation with anti-CaSR antibodies upregulated components of the transcellular calcium transport pathway, including transient receptor potential vanilloid 5 (TRPV5) and calbindin-D28k (CaBP-D28k), and elevated serum calcitriol level, indicating activation of a vitamin D-dependent regulatory axis. Furthermore, anti-CaSR increased the expression of key phosphate transporters in both the intestine and kidney, supporting its broader role in mineral homeostasis. These findings demonstrate that anti-CaSR antibodies enhance the expression of calcium and phosphorus transport proteins, thereby improving mineral retention and promoting bone mineralization in broilers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.