Evidence map›Paper›PMID 42829920›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Single-Nucleus Atlas of Spinal Sarcopenia Patients Reveals Disruption of Quiescent and Regenerative Satellite Cell Niches in Fatty-Infiltrated Muscle.

Wenkai Wu, Renxian Wang, Dingding Wang, Quanzhong Ren, Ling Wang, Fangfang Duan, Guihe Yang, Ruixuan Yu, Yi Wang, Yingyu Zhang and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Wenkai Wu *Department of Spine Surgery, Beijing Jishuitan Hospital, National Centre for Orthopaedics, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0002-9691-5023
Renxian Wang *JST sarcopenia Research Centre, Beijing Research Institute of Traumatology and Orthopaedics, National Center for Orthopaedics, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0002-3330-2895
Dingding Wang *JST sarcopenia Research Centre, Beijing Research Institute of Traumatology and Orthopaedics, National Center for Orthopaedics, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0003-1529-3152
Quanzhong Ren *JST sarcopenia Research Centre, Beijing Research Institute of Traumatology and Orthopaedics, National Center for Orthopaedics, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0009-0002-7726-9182
Ling Wang *Department of Radiology, Beijing Jishuitan Hospital, National Centre for Orthopaedics, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0002-5129-4999
Fangfang DuanClinical Epidemiology Research Center, Beijing Jishuitan Hospital, National Centre for Orthopaedics, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0002-9395-4502
Guihe YangDepartment of Spine Surgery, Beijing Jishuitan Hospital, National Centre for Orthopaedics, Capital Medical University, Beijing, China.
Ruixuan YuDepartment of Spine Surgery, Beijing Jishuitan Hospital, National Centre for Orthopaedics, Capital Medical University, Beijing, China.
Yi WangDepartment of Spine Surgery, Beijing Jishuitan Hospital, National Centre for Orthopaedics, Capital Medical University, Beijing, China.ORCID https://orcid.org/0009-0002-3752-1152
Yingyu ZhangDepartment of Spine Surgery, Beijing Jishuitan Hospital, National Centre for Orthopaedics, Capital Medical University, Beijing, China.
Zetong ZangDepartment of Spine Surgery, Beijing Jishuitan Hospital, National Centre for Orthopaedics, Capital Medical University, Beijing, China.
Chuqi LiDepartment of Spine Surgery, Beijing Jishuitan Hospital, National Centre for Orthopaedics, Capital Medical University, Beijing, China.
Weijia LiuJST sarcopenia Research Centre, Beijing Research Institute of Traumatology and Orthopaedics, National Center for Orthopaedics, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China.
Wenshuang ZhangDepartment of Radiology, Beijing Jishuitan Hospital, National Centre for Orthopaedics, Capital Medical University, Beijing, China.
Yi YuanDepartment of Radiology, Beijing Jishuitan Hospital, National Centre for Orthopaedics, Capital Medical University, Beijing, China.
Zitong ChengDepartment of Radiology, Beijing Jishuitan Hospital, National Centre for Orthopaedics, Capital Medical University, Beijing, China.ORCID https://orcid.org/0009-0005-9218-7742
Xiaoguang ChengDepartment of Radiology, Beijing Jishuitan Hospital, National Centre for Orthopaedics, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0002-4596-8248
Junbo LiangUnion Medical University, Center for Bioinformatics, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking, Union Medical College, Beijing, China.
Yajun LiuDepartment of Spine Surgery, Beijing Jishuitan Hospital, National Centre for Orthopaedics, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0002-0514-6055

Funding

Beijing Hospitals Authority's Ascent Plan DFL20220401Beijing Municipal Health Commission BJRITO-RDP-2025Beijing Postdoctoral Research Foundation 2023-zz-030Talent program of Ministry of Science and Technology SQ2022RA2A000031The Youth Beijing Scholars Program 025
6 · The paper itself

Abstract

Severe muscle fat infiltration is a contributing factor to muscle loss, particularly in the spinal sarcopenia population. However, the underlying mechanism largely remains elusive. Here, we identified the intramuscular fat fraction (IMFF), rather than perimuscular fat fraction, as an independent determinant of trunk muscle strength. Individuals with higher IMFF (10-15% and >15%) exhibited significantly lower paraspinal muscle mass and strength compared to those with lower IMFF (<5%). Using single-nucleus RNA sequencing, we established the first cellular atlas of fat-infiltrated paraspinal muscle, revealing profound remodeling of muscle architecture, extracellular matrix organization, and satellite cell niches. Among the adipose-derived factors, ANGPTL4 emerged as a key paracrine suppressor of myogenesis, acting through upregulation of syndecan-2 (SDC2) in satellite cells. Inhibition of SDC2 partially rescued ANGPTL4-induced myogenic impairment in C2C12 cells. Furthermore, we identified a GPC3

Indexed as

adipokinefatty infiltrationmicroenvironmentsequencingspinal sarcopenia

Identifiers

PMID42829920
PMCPMC13634468

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.