ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Conjugated Polymer-Microbe Interactions Trigger Regulatory Reprogramming for Enhanced Bioelectrocatalysis.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Abiotic redox-active materials are increasingly used to interface with electroactive microorganisms, yet their influence on cellular regulation remains poorly understood. Here, Shewanella oneidensis MR-1 was coupled with the electron-transporting conjugated polymer poly(benzodifurandione) (PBFDO) to examine how material interfaces reshape inward extracellular electron transfer (EET). PBFDO-coated carbon electrodes enhanced electron uptake and fumarate reduction, producing over two orders of magnitude higher current density and up to a twelvefold increase in succinate production than polymer-free controls. Integrated electrochemical, transcriptomic, metabolomic, and protein analyses reveal coordinated physiological remodeling associated with the polymer-supported interface rather than passive conductivity alone. PBFDO exposure is associated with transcriptional enrichment of genes linked to the Mtr-CymA electron-transfer conduit, energy metabolism, and biofilm formation. Metabolomics revealed altered intracellular redox and metabolite profiles consistent with enhanced fumarate respiration, alongside elevated NADH/NAD
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