Evidence map›Paper›PMID 42829807›Full record

Trial reportJournal of the International Society of Sports Nutrition2026

Modulating stress and sleep through a multi-compound dietary supplement: a randomized, double-blind, placebo-controlled trial.

Gianna F Mastrofini, Riccardo F Romersi, Maria G Lombardi, Katelynn T Persaud, Monica M Ryan, Katie R Hirsch, Amy L Fraley, J Jay Dawes, Sten O Stray-Gundersen, James W Hardin and 1 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of the International Society of Sports Nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Gianna F MastrofiniArnold School of Public Health, University of South Carolina, Department of Exercise Science, Columbia, SC, United States.ORCID 0000-0002-6716-5200
Riccardo F RomersiArnold School of Public Health, University of South Carolina, Department of Exercise Science, Columbia, SC, United States.ORCID 0009-0004-6616-8014
Maria G LombardiArnold School of Public Health, University of South Carolina, Department of Exercise Science, Columbia, SC, United States.
Katelynn T PersaudArnold School of Public Health, University of South Carolina, Department of Exercise Science, Columbia, SC, United States.
Monica M RyanArnold School of Public Health, University of South Carolina, Department of Exercise Science, Columbia, SC, United States.
Katie R HirschArnold School of Public Health, University of South Carolina, Department of Exercise Science, Columbia, SC, United States.ORCID 0000-0002-0899-0139
Amy L FraleyArnold School of Public Health, University of South Carolina, Department of Exercise Science, Columbia, SC, United States.ORCID 0000-0001-6439-3075
J Jay DawesSchool of Kinesiology, Oklahoma State Univeristy, Department of Applied Health and Recreation, Stillwater, OK, United States.ORCID 0000-0002-2668-8873
Sten O Stray-GundersenArnold School of Public Health, University of South Carolina, Department of Exercise Science, Columbia, SC, United States.ORCID 0000-0002-1395-8467
James W HardinArnold School of Public Health, University of South Carolina, Department of Epidemiology and Biostatistics, Columbia, SC, United States.ORCID 0000-0003-0506-5500
Shawn M ArentArnold School of Public Health, University of South Carolina, Department of Exercise Science, Columbia, SC, United States.ORCID 0000-0003-0647-0591

Funding

Biomedical-Behavioral Interface: Prevention and Developmental Sciences TrainingT32GM081740 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI PRINZ, RONALD J · 2008 to 2022
$4.5M
NIGMS NIH HHS T32 GM081740
6 · The paper itself

Abstract

backgroundStress and poor sleep are prevalent public health concerns that negatively impact well-being and daily functioning. Although adaptogens and sleep-focused supplements have separately demonstrated potential benefits, few studies have examined combined effects, particularly in healthy populations. Therefore, this study evaluated the impact of morning adaptogens, evening sleep-focused supplements, and their combination on stress, mood, and subjective and objective sleep quality.

methodsUsing a double-blind, placebo-controlled design, 103 healthy physically active adults (F = 53; age = 34.8 ± 9.6 yrs; BMI = 24.0 ± 2.7 kg/m

resultsThe AM group showed a decrease in weekly perceived stress (

conclusionsMorning supplementation with adaptogens (ashwagandha and

Indexed as

Dietary SupplementsSleepStress, PsychologicalAdultAffectDouble-Blind MethodFemaleGlutamatesHumansMaleMiddle AgedSleep DurationSleep QualitySubjective StressYoung AdultGlutamatestheanineAdaptogensmoodperceived stresssleep disturbancesleep quality

Identifiers

PMID42829807
PMCPMC13644447

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.