ReviewEJHaem2026
Long-Term Outcomes of Exercise-Based Rehabilitation and Immunometabolic Parameters in Adult Haematopoietic Stem Cell Transplant Recipients: An Updated Systematic Review of Randomised Controlled Trials.
Review in EJHaem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Adult haematopoietic stem cell transplantation (HSCT) survivors have deficits in physical function, fatigue and quality of life that differ between autologous and allogeneic recipients. Few randomised controlled trials (RCTs) have evaluated exercise at 3 months or more, and immune reconstitution is rarely assessed. We synthesised RCT evidence on longer-term exercise effects across physical, psychosocial and immunometabolic outcomes by transplant type. Methods: Following PRISMA 2020, six databases were searched (2019-2026) for RCTs comparing structured exercise with usual care or control in adults after HSCT, with outcomes at 3 months or more. Screening, extraction and risk-of-bias appraisal (Cochrane RoB 2) were conducted independently by two reviewers. Heterogeneity precluded meta-analysis; findings were synthesised narratively with GRADE certainty ratings. Results: Seven RCTs (529 participants; two allogeneic, two autologous and three mixed) reported no serious exercise-related adverse events. Between-group 6-min walk distance improved by approximately 51-63 m (significant in the largest trial) and sit-to-stand by 2.5-3.8 repetitions. Cardiorespiratory fitness, fatigue and quality-of-life effects were inconsistent, often within-group only. Benefit appeared larger in allogeneic recipients, whereas an autologous trial showed none. Immunometabolic data from two trials showed an exploratory reduction in soluble ICAM-1 and within-group recovery of body cell mass. Certainty was low to very low. Conclusions: Exercise appears safe after HSCT and may improve objective physical function, with the greatest benefits observed in allogeneic and more impaired recipients. Cardiorespiratory, fatigue and quality-of-life effects remain uncertain, and immunometabolic evidence is preliminary. Future trials should report outcomes by transplant type and incorporate immune and metabolic endpoints with longer follow-ups. Trial registration: The authors confirm that clinical trial registration is not needed for this submission.
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